Objective To investigate the clinical feasibility, safety and advantages of transumbilical laparoscopic single-site surgery in large hysterectomy.

Methods A total of 82 patients with laparoscopic large hysterectomy were selected as the study objects. Among them, 41 patients underwent transumbilical single-hole laparoscopic surgery (single-hole group) and 41 patients underwent traditional multi-hole laparoscopic surgery (multi-hole group). Operation time, intraoperative blood loss, 24 h postoperative Visual Analogue Score (VAS), postoperative exhaust time, postoperative morbidity, postoperative hospital stay, cosmetic incision score, postoperative inflammatory index, neutrophil lymphocyte ratio (NLR), incidence of complications and the difference of hemoglobin before and after surgery were compared between the two groups.

Results The operation was successfully completed in both groups without conversion to laparotomy, and no serious surgical complications occurred. No auxiliary holes were added in the single-hole group. The postoperative exhaust time in the single-hole group was significantly shorter than that in the multi-hole group, the VAS score at 24 h after surgery and NLR at the first day after surgery were significantly lower than those in the multi-hole group, and the aesthetic score of the postoperative incision was significantly higher than that in the multi-hole group (P < 0.05).

Conclusion Under the condition of strict control of surgical indications, transumbilical laparoscopic single-site surgery in large hysterectomy has good safety and high feasibility, and has the advantages of fast postoperative exhaust, relieved postoperative pain, light immunosuppression and a incision.