Objective To explore the effect of chlorophyll derivative on wound healing after hemorrhoidectomy.

Methods A total of 124 patients with circular hemorrhoids after procedure for prolapse and hemorrhoids (PPH) were selected and divided into control group and experimental group. The granulation formation time, wound healing time, degree of wound edema and pain before and after treatment, serum biochemical indicators, adverse reactions and complications were compared between two groups.

Results The granulation formation time and wound healing time in the experimental group were significantly shorter than those in the control group (P < 0.05). After treatment, wound edema score and pain score as well as serum levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in both groups were significantly lower than those before treatment, and these indexes after treatment in the experimental group were significantly lower than those in the control group (P < 0.05), but the differences of the above indexes before and after treatment in the experimental group were significantly higher than those in the control group (P < 0.05). After treatment, the levels of serum epidermal growth factor (EGF), fibronectin (FN) and basic fibroblast factor (bFGF) in both groups increased significantly, and these indexes after treatment in the experimental group were significantly higher than those in the control group (P < 0.05).

Conclusion Chlorophyll derivative can promote granulation formation and wound healing after hemorrhoidectomy, and reduce degrees of edema and pain.