Objective To observe the clinical effect of trimodal pre-rehabilitation strategy in patients undergoing pancreatoduodenectomy.

Methods A total of 110 patients undergoing elective pancreaticoduodenectomy were selected as the study objects. Patients were randomly divided into control group and observation group according to the odd-even order, with 55 cases in each group. The control group was given routine nursing during perioperative period, and the observation group was given trimodal pre-rehabilitation nursing before surgery based on the control group. The psychological state, quality of life, postoperative indexes and complications of the two groups were observed and compared. Serum albumin (ALB), prealbumin (PA) and transferrin (TRF) levels were detected in two groups.

Results Postoperative exhaust time, getting out of bed time, first oral feeding time and hospital stay in the observation group were significantly shorter than those in the control group (P < 0.05). At 1 day before surgery and 14 days after surgery, the levels of ALB, PA, TRF and 36-item Short Form Health Assessment Scale (SF-36) in the observation group were significantly higher than those in the control group, and the Hospital Anxiety and Depression Scale (HADS) scores were significantly lower than those in the control group (P < 0.01 or P < 0.05). The incidence of pulmonary infection and venous thrombosis in the observation group was significantly lower than that in the control group (P < 0.05).

Conclusion Trimodal pre-rehabilitation nursing intervention can effectively improve the perioperative nutritional status and psychological state of patients with pancreaticoduodenectomy, improve their quality of life and reduce the incidence of complications.