Objective To investigate the correlations of serum osteocalcin (OCN) level and bone mineral density (BMD) of depression status in Parkinson's disease (PD) patients with depression.

Methods A total of 66 patients with PD(PD group) and 49 healthy people(healthy control group) were selected as study objects. The general clinical data, serum OCN level, BMD of lumbar spine and left femoral neck between two groups were compared. According to Hamilton Depression Scale-17 (HAMD-17) score, PD patients were divided into PD with depression group (n=41) and PD without depression group (n=25). The general clinical data, serum OCN level, BMD of lumbar spine and left femoral neck were compared between the two groups. Pearson correlation analysis was used to investigate the correlations of serum OCN level, BMD of lumbar spine and left femoral neck with depression score and anxiety score of PD patients. Multivariate Logistic regression analysis was used to determine the influencing factors of PD patients with depression.

Results Compared with healthy control group, serum OCN level and BMD of lumbar spine and left femoral neck in the PD group were significantly decreased (P < 0.05). The level of serum OCN and BMD of lumbar spine and left femoral neck in the PD with depression group were significantly lower than those in the PD without depression group(P < 0.05). Serum OCN level, BMD of lumbar spine and left femoral neck in PD patients were significantly correlated with depression and anxiety scores (P < 0.05). Decreased serum OCN level and decreased BMD in lumbar spine and left femoral neck were independent risk factors for PD with depression (P < 0.05).

Conclusion Serum OCN level, BMD of lumbar spine and BMD of left femoral neck are closely related to PD patients with depression, which may provide a reference for the clinical prevention and treatment of depression in PD patients.