产妇产后创伤后应激障碍的列线图预测模型构建及验证

Construction of predictive nomogram model for postpartum post-traumatic stress disorder in pregnant women after delivery

  • 摘要:
    目的 分析产妇产后创伤后应激障碍(PP-PTSD)的影响因素,构建预测PP-PTSD发生风险的列线图模型并验证效能。
    方法 纳入1 027例分娩后42 d产妇作为研究对象,按照7∶3的比例随机分为模型组719例和验证组308例,根据是否发生PP-PTSD将模型组产妇分为PP-PTSD组和非PP-PTSD组。应用病例调查表、焦虑自评量表(SAS)、创伤后应激障碍量表-平民版(PCL-C)、领悟社会支持量表(PSSS)、爱丁堡产后抑郁量表(EPDS)调查产妇状况,采用Logistic回归模型分析PP-PTSD的影响因素,通过R软件绘制列线图模型,并通过受试者工作特征(ROC)曲线、校准曲线、H-L检验对模型的预测效能进行验证。
    结果 1 027例产妇中, 136例(13.24%)产妇于产后42 d内出现PP-PTSD症状阳性,其中模型组94例、验证组42例。PP-PTSD组剖宫产率、EPDS评分、有妊娠糖尿病者占比、新生儿5 min Apgar评分0~7分者占比、SAS评分高于非PP-PTSD组, PSSS评分低于非PP-PTSD组,差异有统计学意义(P < 0.05)。多因素Logistic回归分析结果显示, EPDS评分、分娩方式、妊娠糖尿病、SAS评分、新生儿5 min Apgar评分、PSSS评分均为产妇发生PP-PTSD的独立影响因素(P < 0.05)。基于上述6个影响因素构建列线图预测模型,该模型在模型组中预测PP-PTSD的曲线下面积(AUC)为0.930(95%CI: 0.905~0.955), 敏感度、特异度分别为89.40%、87.40%, 校准曲线斜率接近1, H-L检验结果示χ2=8.873, P=0.409; 该模型在验证组中预测PP-PTSD的AUC为0.900(95%CI: 0.850~0.950), 特异度、敏感度分别为86.90%、84.50%, 校准曲线斜率均接近1, H-L检验结果显示χ2=6.089, P=0.457。
    结论 产妇发生PP-PTSD的影响因素包括社会支持水平、是否剖宫产、有无妊娠糖尿病、产后抑郁、新生儿5 min Apgar评分、焦虑状态, 据此构建的列线图模型对产妇PP-PTSD发生风险具有较好的预测价值。

     

    Abstract:
    Objective To analyze the influencing factors of postpartum post-traumatic stress disorder (PP-PTSD) in pregnant women, and construct a predictive nomogram model for occurrence of PP-PTSD to verify its efficacy.
    Methods A total of 1 027 pregnant women after delivery of 42 days were included and randomly divided into model group (719 cases) and validation group (308 cases) at a ratio of 7∶3. They were divided into PP-PTSD group and non-PP-PTSD group based on whether PP-PTSD occurred. The maternal status was conducted using a case study questionnaire, a Self-rating Anxiety Scale (SAS), a PTSD Checklist-Civilian Version (PCL-C), a Perceived Social Support Scale (PSSS), and the Edinburgh Postnatal Depression Scale (EPDS). Logistic regression model was applied to analyze the influencing factors of PP-PTSD, and R software was applied to draw a nomogram model, and the predictive efficiency of the model was verified by receiver operating characteristic (ROC) curve, calibration curve and H-L test.
    Results Within 42 days after delivery, 136 (13.24%) of 1 027 pregnant women had positive PP-PTSD symptoms, including 94 cases in the model group and 42 cases in the validation group. The cesarean section rate, EPDS score, proportion of patients with gestational diabetes mellitus, 5 min Apgar score of newborns (0 to 7), SAS score in the PP-PTSD group were higher, and PSSS score of was lower than that of the non-PP-PTSD group. Logistic regression model showed that EPDS score, delivery mode, gestational diabetes mellitus, SAS score, 5 min Apgar score for neonates and PSSS score were all independent influencing factors for the occurrence of PP-PTSD(P < 0.05). A nomogram prediction model was constructed based on the above 6 influencing factors. The area under the curve (AUC) of the model group to predict PP-PTSD was 0.930(95%CI, 0.905 to 0.955), the sensitivity and specificity were 89.40% and 87.40%, respectively. The slope of calibration curve was close to 1. H-L test showed that chi-square value was 8.873 and P value was 0.409. In the verification group, the model predicted that the AUC of PP-PTSD was 0.900 (95%CI, 0.850 to 0.950), the specificity and sensitivity were 86.90% and 84.50%, respectively, and the slope of the calibration curve was close to 1. The H-L test showed that chi-square value was 6.089, and P value was 0.457.
    Conclusion The influencing factors of PP-PTSD in parturients include social support status, cesarean section, pregnancy complicating with diabetes, postpartum depression, Apgar score at 5 minutes, and anxiety state. The nomogram model constructed on above factors has a good predictive value for the occurrence of PP-PTSD in parturients.

     

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