Abstract: Disulfidptosis is a new cell death mode in malignant tumors. Cell death has evolved from multiple regulatory cell death and accidental cell death, including apoptosis, cellular pyroptosis, necroptosis, and iron and copper death. Disulfidptosis is a new cell death mechanism that triggers cells to undergo cell death when cells with high expression of the solute carrier family 7 member 11(SLC7A11) protein are subjected to glucose starvation. The identification and characterization of mechanisms targeting the regulation of cell death not only promotes a fundamental understanding of cellular homeostasis, but also provides important ideas for the treatment of malignant tumors.