腹膜透析患者血清甘油三酯空腹葡萄糖乘积与肾性贫血的相关性研究

李洁; 王加英; 张圆圆; 徐德宇; 胡坤; 周玲; 卢国元

doi:10.7619/jcmp.20232446

腹膜透析患者血清甘油三酯空腹葡萄糖乘积与肾性贫血的相关性研究

Correlation of the product of serum triglyceride and fasting plasma glucose with renal anemia in peritoneal dialysis patients

摘要

摘要:
目的评估血清甘油三酯空腹葡萄糖乘积(TFM)与腹膜透析(PD)患者肾性贫血的相关性。
方法纳入苏州大学附属第一医院肾内科行PD充分性评估的PD患者为研究对象, 收集所有患者的临床及实验室资料并计算TFM。采用Pearson及Spearman法评估各指标与TFM的相关性，比较不同贫血程度PD患者的TFM差异。采用多因素Logistic回归分析探讨TFM与肾性贫血严重程度的关系。
结果本研究共纳入PD患者137例，血红蛋白≥110 g/L者TFM高于血红蛋白 < 110 g/L者，差异有统计学意义(P=0.014)。二元Logistic回归分析提示, TFM增加时，中重度贫血的发生风险下降(OR=0.896, P=0.015)。
结论 PD患者TFM与肾性贫血密切相关, TFM较高时，中重度贫血发生风险下降。

Abstract:
Objective To evaluate the correlation of the product of triglyceride and fasting plasma glucose (TFM) with renal anemia in peritoneal dialysis(PD)patients.
Methods PD patients who received adequate evaluation in the Department of Nephrology of the First Hospital Affiliated to Soochow University were included. All clinical and laboratory data were collected and TFM was calculated. Pearson and Spearman methods were used to evaluate the correlations of these clinical and laboratory indicators with TFM in PD patients. The difference of TFM in PD patients with different anemia degree was compared. Multivariate Logistic regression was used to analyze the relationship between TFM and the severity of renal anemia.
Results A total of 137 PD patients were included. TFM in PD patients with Hb ≥110 g/L was significantly higher than those with Hb < 110 g/L(P=0.014). Binary Logistic regression suggested that the risk of moderate to severe anemia decreased with increasing TFM (OR=0.896, P=0.015).
Conclusion TFM is closely related to renal anemia in PD patients. The risk of moderate to severe anemia decreases with the increase of TFM.

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