组蛋白甲基化修饰在衰老性心血管病变中的研究进展

孟迪; 张静; 曾萍; 刘丽; 吴静宜; 黄逸凡; 杨简

doi:10.7619/jcmp.20232373

组蛋白甲基化修饰在衰老性心血管病变中的研究进展

孟迪^{1, 2, 3, 4},
张静^{1, 2, 3, 4},
曾萍^{1, 2, 3},
刘丽^{1, 2, 3, 4},
吴静宜^{1, 2, 3},
黄逸凡^{1, 2, 3},
杨简^{1, 2, 3, ,}

1.
三峡大学第一临床医学院/湖北省宜昌市中心人民医院心血管内科, 湖北宜昌, 443000
2.
三峡大学心血管病研究所, 湖北宜昌, 443000
3.
湖北省缺血性心血管疾病临床医学研究中心, 湖北宜昌, 443000
4.
湖北省宜昌市中心人民医院中心实验室, 湖北宜昌, 443000

基金项目:

国家自然科学基金项目 82070372

国家自然科学基金项目 82170418

国家自然科学基金项目 82271618

湖北省自然科学基金创新群体项目 2022CFA015

湖北省教育厅重点项目 D20221205

湖北省科技创新基地条件平台专项 2022DCC014

湖北省重点研发计划 2022BCE001

湖北省卫生健康委面上项目 WJ2023M151

详细信息

通讯作者:
杨简, E-mail: yangjian@ctgu.edu.cn

中图分类号: R541;R543;R34
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- 文章访问数: 149
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出版历程
- 收稿日期: 2023-07-26
- 修回日期: 2023-09-14
- 网络出版日期: 2023-12-25
- 刊出日期: 2023-12-14

Research progress on histone methylation modification in aging cardiovascular disease

MENG Di^{1, 2, 3, 4},
ZHANG Jing^{1, 2, 3, 4},
ZENG Ping^{1, 2, 3},
LIU Li^{1, 2, 3, 4},
WU Jingyi^{1, 2, 3},
HUANG Yifan^{1, 2, 3},
YANG Jian^{1, 2, 3, ,}

1.
Department of Cardiovascular Diseases, the First Clinical Medical College of China Three Gorges University, Yichang City Central People's Hospital in Hubei Province, Yichang, Hubei, 443000
2.
Institute of Cardiovascular Diseases of China Three Gorges University, Yichang, Hubei, 443000
3.
Hubei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, Hubei, 443000
4.
Central Laboratory, Yichang City Central People's Hospital in Hubei Province, Yichang, Hubei, 443000

摘要

摘要:
关注心肌衰老、瓣膜改变、心脏传导系统改变及血管老化等心脏结构和功能的改变，对研究衰老相关心血管疾病的治疗方法至关重要。组蛋白甲基化修饰参与调控基因表达，与衰老性心血管疾病的发生发展密切相关。本文就组蛋白甲基化修饰在心脏结构和功能改变中的作用进行综述，为衰老性心血管病变的研究提供新的理论依据。
- 组蛋白甲基化修饰 /
- 心肌衰老 /
- 瓣膜 /
- 心脏传导系统 /
- 血管老化 /
- 衰老
Abstract:
Changes in cardiac structure and function such as myocardial aging, valve alterations, alterations in the cardiac conduction system and vascular aging are crucial for studying therapeutic methods for age-related cardiovascular diseases. Histone methylation modification is involved in the regulation of gene expression and closely related to the occurrence and development of age-related cardiovascular diseases. This paper provided a comprehensive review on the role of histone methylation modification in cardiac structural and functional changes, providing new theoretical basis for age-related cardiovascular diseases.
- histone methylation modification /
- myocardial aging /
- valves /
- cardiac conduction system /
- vascular aging /
- aging

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参考文献(51)

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组蛋白甲基化修饰在衰老性心血管病变中的研究进展

通讯作者: 杨简, E-mail: yangjian@ctgu.edu.cn

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出版历程

Research progress on histone methylation modification in aging cardiovascular disease

计量

出版历程

目录

通讯作者:
杨简, E-mail: yangjian@ctgu.edu.cn