Objective To implement metrological and visual analysis for literatures related to microdialysis technology in pharmacokinetic field in Web of Science database (WOS).

Methods The literature related to microdialysis technology in the field of pharmacokinetics in the core collection of WOS was analyzed, with the year of publication, country as well as subject terms, keywords and frequently cited references as indicators.

Results A total of 604 articles were included. From 2013 to 2015, the number of publications per year was 55. From 2016 to 2023, the number of publications per year stabilized at about 60. In the past 10 years, the cumulative number of published documents had shown a linear growth. The country with the highest number of articles was China (193 articles). From 2013 to 2018, the most common keywords were"brain microdialysis" "mice" and "Parkinson disease", etc. From 2019 to 2023, the most common keywords were "morbidly obese" "children" "cerebral microdialysis" "bone" "surgical site infection" and "antibiotic" prophylaxis", etc.

Conclusion At present, microdialysis technology is widely used in the field of basic pharmacokinetics, and it may play an important role in clinical practice such as peripheral tissue delivery, drug concentration monitoring and neurocritical care in the future.