最大直径2 cm内的不同分子分型乳腺癌超声特征及诊断价值

丛小宇; 笪应芬; 汪成; 梁新凤; 陈民; 袁杰

doi:10.7619/jcmp.20232343

最大直径2 cm内的不同分子分型乳腺癌超声特征及诊断价值

Ultrasonic characteristics and diagnostic value of different molecular types of breast cancer with maximum diameter within 2 cm

摘要

摘要:
目的探讨最大直径≤2 cm不同分子分型乳腺癌的临床病理及超声特征, 分析常规超声的诊断价值。
方法选取174例最大直径≤2 cm乳腺癌患者为研究对象，根据免疫组化结果分为LA组(Luminal A型, n=46)、LB组(Luminal B型, n=71)、HER-2组(HER-2过表达型, n=11)及三阴组(三阴性, n=46)。分析各组的临床病理、超声特征及常规超声诊断的准确率。
结果 4组乳腺癌大小、病理分级、病理类型比较，差异有统计学意义(P < 0.05)。超声特征中, 4组的形态、边缘、纵横比、钙化、后方回声比较，差异有统计学意义(P < 0.05)。4组乳腺癌乳腺影像报告和数据系统(BI-RADS)分级、常规超声诊断准确率比较，差异有统计学意义(P < 0.05)。
结论最大直径≤2 cm不同分子分型乳腺癌的临床病理、超声特征及BI-RADS分级有一定差异。常规超声具有一定的诊断价值，可为早期乳腺癌分子分型诊断、个体化治疗以及预后评估提供重要的参考依据。

Abstract:
Objective To investigate the clinicopathological and ultrasonic characteristics of different molecular types of breast cancer with maximum diameter ≤2 cm, and analyze the diagnostic value of conventional ultrasound.
Methods A total of 174 breast cancer patients with diameter ≤2 cm were selected as the study objects. According to the immunohistochemical results, they were divided into LA group (Luminal A, n=46), LB group (Luminal B, n=71), HER-2 group (HER-2 overexpression type, n=11) and triple-negative group (triple-negative, n=46). The clinicopathology, ultrasonic characteristics and the accuracy of conventional ultrasonic diagnosis were analyzed.
Results There were significant differences in breast cancer size, pathological grade and pathological type among four groups (P < 0.05). Among the ultrasonic characteristics, there were statistically significant differences in shape, edge, aspect ratio, calcification and rear echo among the four groups (P < 0.05). Breast Imaging Reporting and Data System (BI-RADS) grading and accuracy of conventional ultrasound diagnosis among the four groups showed statistically significant differences (P < 0.05).
Conclusion The clinicopathological features, ultrasound features and BI-RADS grading of different molecular types of breast cancer with maximum diameter ≤2 cm are different. Routine ultrasound has certain diagnostic value, which can provide important reference for molecular classification diagnosis, individualized treatment and prognosis evaluation of early breast cancer.

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