Objective To observe the effect of pre-hospital and intra-hospital collaborative therapeutic model in the treatment of patients with acute cerebral infarction.

Methods A total of 67 patients with acute cerebral infarction were selected as the research objects, and they were divided into observation group (n=37) and control group (n=30) according to the therapeutic model. The control group was conducted with the traditional therapeutic model, while the observation group was conducted with the pre-hospital and intra-hospital collaborative therapeutic model. The time efficiency of intravenous thrombolysis, early recovery of nerve function and oxidative stress indexes were compared between the two groups.

Results There was no significant difference in the time from onset to visit between the two groups (P > 0.05); the time from seeing a doctor to thrombolysis and the time from seeing a doctor to signing the informed consent for intravenous thrombolysis in the observation group were significantly shorter than those in the control group (P < 0.05). On the hospital admission, there was no significant difference in the National Institutes of Health Stroke Scale (NIHSS) score between the two groups (P > 0.05); at the time points of 7 days after admission and 90 days after thrombolysis, the NIHSS scores of patients in the observation group were significantly lower than that in the control group (P < 0.05). There were no significant differences in the levels of serum glutathione peroxidase (GSH-Px) and malonaldehyde (MDA) between the two groups (P > 0.05); the level of serum superoxide dismutase (SOD) in the observation group was significantly higher than that in the control group (P < 0.05). One patient died in the control group, with a mortality rate of 3.33%; no patient died in the observation group.

Conclusion Pre-hospital and intra-hospital collaborative therapeutic model can effectively improve the time efficiency of intravenous thrombolysis for patients with acute cerebral infarction, alleviate the neurological damage, and reduce degree of oxidative stress reaction and death risk.