Objective To investigate the effect of laparoscopic sleeve gastrectomy in treatment of obese patients and its influence on intestinal flora.

Methods Thirty obese hospitalized patients were collected. All patients received laparoscopic sleeve gastrectomy. The operation time and intraoperative blood loss, postoperative hospitalization duration, anal exhaust time and occurrence of postoperative complications wereobserved. The patients were followed up for 6 months after discharge, and body weight, body mass index (BMI), waist circumference and other indicators at 1 month, 3 months and 6 months after the operation were observed, and the improvement of related diseases and changes of intestinal flora were observed.

Results The body mass, BMI and waist circumference of 30 obese patients at 1 month, 3 and 6 months after surgery were lower or smaller than those before surgery (P < 0.05). The follow-up results showed that the related co-morbidities of the patients were significantly improved. Compared with pre-operation, the levels of total cholesterol, triglyceride and low-density lipoprotein cholesterol decreased after operation, while the level of high-density lipoprotein cholesterol increased (P < 0.05). At the hilum level, the abundance of Bacteroidetes at 1 month, 3 months and 6 months after the operation increased significantly after surgery compared with the preoperation(P < 0.05). At the genus level, the abundance of Bacteroidetes and Prevotella was higher than those before operation, and the abundance of Prevotella Pseudomonas was lower than those before operation (P < 0.05).

Conclusion Laparoscopic sleeve gastrectomy has a good therapeutic effect for obese patients, which can reduce the body mass of patients in a short period of time and effectively regulate the intestinal flora of patients.