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富血小板纤维蛋白联合泡沫敷料治疗慢性感染伤口的疗效及抑菌作用分析

Efficacy and bacteriostasis of platelet-rich fibrin combined with foam dressing in treating chronic infection wound

    摘要
  • 摘要:
    目的 观察富血小板纤维蛋白(PRF)联合泡沫敷料治疗慢性感染伤口的效果及抑菌作用。
    方法 选取慢性伤口感染接受治疗的患者90例，以随机数字表法分为对照组和实验组，每组45例。对照组接受泡沫敷料治疗，实验组予以PRF联合泡沫敷料治疗。比较2组治疗后14 d总有效率、创面恢复情况(换药次数、创面面积减少量); 比较2组治疗后3、7 d疼痛评分; 比较2组治疗后7、14 d细菌转阴率及治疗后14 d血清白细胞(WBC)水平、血清C反应蛋白(CRP)水平、血清降钙素原(PCT)水平、血清白细胞介素-6(IL-6)水平。
    结果 治疗14 d后，实验组、对照组的总有效率分别为100.00%和77.78%, 差异有统计学意义(P < 0.05); 治疗后，实验组、对照组换药次数分别为(4.39±5.48)次和(11.12±1.36)次，差异有统计学意义(P < 0.05); 实验组、对照组创面面积减少量分别为(14.98±1.73) cm2和(11.26±1.35) cm2, 差异有统计学意义(P < 0.05); 实验组治疗后3、7 d疼痛评分较对照组低，差异有统计学意义(P < 0.05); 治疗后14 d, 实验组、对照组细菌转阴率分别为100.00%、58.62%, 差异有统计学意义(P < 0.05); 治疗后14 d, 实验组WBC、CRP、PCT、IL-6水平较对照组低，差异有统计学意义(P < 0.05)。
    结论 PRF联合泡沫敷料治疗慢性感染伤口能够显著提高治疗效果，促进伤口愈合，缓解疼痛，抑制细菌感染，并减轻炎症反应。

     

    Abstract:
    Objective To observe the efficacy and bacteriostasis of platelet-rich fibrin (PRF) combined with foam dressing in treating chronic infection wound.
    Methods A total of 90 patients with chronic infection wound were selected and randomly divided into control group and experimental group, with 45 cases in each group. The control group was treated with foam dressing, and the experimental group was treated with PRF and foam dressing. The total effective rate and wound recovery condition (the number of dressing changes and reduction in wound area) after 14 days of treatment were compared between the two groups; the pain scores at 3 and 7 days after treatment were compared between the two groups; the bacterial negative conversion rates at 7 and 14 days after treatment as well as the levels of serum white blood cell (WBC), C-reactive protein (CRP), serum procalcitonin (PCT) and serum interleukin-6 (IL-6) at 14 days after treatment were compared between two groups.
    Results After 14 days of treatment, the total effective rate of the experimental group and the control group was 100.00% and 77.78%, respectively, with a significant between-group difference (P < 0.05); after treatment, the number of dressing changes in the experimental group and control group was (4.39±5.48) and (11.12±1.36), respectively, with a significant between-group difference (P < 0.05); the reduction in wound area in the experimental group and the control group was (14.98±1.73) cm2 and (11.26±1.35) cm2 respectively, with a significant between-group difference (P < 0.05); the pain score of the experimental group was significantly lower than that of the control group at 3 and 7 days after treatment (P < 0.05); at 14 days after treatment, the bacterial negative conversion rates in the experimental group and the control group were 100.00% and 58.62% respectively, with a significant between-group difference (P < 0.05); at 14 days after treatment, the levels of WBC, CRP, PCT and IL-6 in the experimental group were significantly lower than those in the control group (P < 0.05).
    Conclusion PRF combined with foam dressing can significantly enhance efficacy in the treatment of chronic infection wound, promote wound healing, relieve pain, inhibit bacterial infections and alleviate the inflammatory reactions.

     

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