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不同年龄病理性近视脉络膜新生血管患者黄斑形态和微循环指标比较

A comparison of macular morphology and microcirculation index in patients with pathological myopic choroidal neovascularization at different ages

    摘要
  • 摘要:
    目的 基于光学相干断层成像(OCT)、光学相干断层扫描血管成像(OCTA)检查分析不同年龄病理性近视脉络膜新生血管(PM-CNV)患者黄斑形态和微循环指标。
    方法 选取70例PM-CNV患者(均为单眼发病, 共纳入70眼)作为研究对象，根据年龄的不同分为≤50岁组18例(18眼)和>50岁组52例(52眼)。所有患者接受眼科常规检查、OCT检查、OCTA检查，比较2组的基本特征最佳矫正视力(BCVA)、等效球镜度数(SE)、眼轴、黄斑形态指标黄斑中心凹视网膜厚度(CMT)、中心凹下内层视网膜厚度(IRT)、中心凹下外层视网膜厚度(ORT)、中心凹下脉络膜厚度(SFCT)、中心凹下外层视网膜结构(Bruch膜、嵌合体带完整性)、微循环指标视网膜浅层毛细血管血流密度(SCP-VD)、视网膜深层毛细血管血流密度(DCP-VD)、脉络膜毛细血管血流密度(CC-VD)和脉络膜新生血管(CNV)相关指标(CNV面积、CNV血流面积、CNV位置)水平。
    结果 2组BCVA、SE、眼轴比较，差异无统计学意义(P>0.05); ≤50岁组SFCT为79.00(51.25, 112.25) μm, 大于>50岁组的39.50(23.50, 63.00) μm, 差异有统计学意义(P < 0.001); 2组CMT、IRT、ORT和中心凹下嵌合体带、Bruch膜完整性比较，差异无统计学意义(P>0.05); ≤50岁组SCP-VD为(40.76±4.75)%, 高于>50岁组的(35.25±6.24)%, 差异有统计学意义(P=0.001); 2组DCP-VD、CC-VD、CNV相关指标水平比较，差异无统计学意义(P>0.05)。
    结论 相较于年龄>50岁的PM-CNV患者，年龄≤50岁的PM-CNV患者SFCT显著更大，且黄斑区SCP-VD显著更高。

     

    Abstract:
    Objective Based on optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA), macular morphology and microcirculation indexes were analyzed in patients with pathological myopia choroidal neovascularization (PM-CNV) at different ages.
    Methods Seventy PM-CNV patients (with monocular disease, 70 eyes in total) were selected as the study objects, and were divided into≤50 years old group18 cases (18 eyes) and >50 years old group52 cases (52 eyes) according to differed age. Routine ophthalmic examination and OCT and OCTA examinations were performed for all eyes. The basic features best corrected visual acuity (BCVA), spherical equivalent (SE), ocular axis, macular morphological indexes central macular thickness (CMT), subfoveal inner retinal thickness (IRT), subfoveal outer retinal thickness (ORT), subfoveal choroidal thickness (SFCT), subfoveal outer retinal structure (Bruch membrane, chimera band integrity), microcirculation indicators superficial retinal capillary blood flow density (SCP-VD), deep retinal capillary blood flow density (DCP-VD), choroidal capillary blood flow density (CC-VD) and choroidal neovascularization (CNV)-related indicator (CNV area, CNV blood flow area, CNV location) levels were compared between the two groups.
    Results There were no significant differences in BCVA, diopter and ocular axis between the two groups (P>0.05). The SFCT of the ≤50 years old group was 79.00(51.25, 112.25)μm, which was higher than 39.50(23.50, 63.00)μm of the >50 years old group (P < 0.001). There was no significant difference in the integrity of CMT, IRT, ORT, subfoveal chimera zone and Bruch membrane between two groups (P>0.05). SCP-VD in the ≤50 years old group was (40.76±4.75) %, which was higher than (35.25±6.24) % in the >50 years old group (P=0.001). There were no significant differences in DCP-VD, CC-VD and CNV levels between the two groups (P>0.05).
    Conclusion PM-CNV patients aged ≤50 has significantly larger SFCT than that in patients aged above 50 years old, and higher SCP-VD in macular region.

     

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