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2型糖尿病患者血糖波动与血清网膜素-1及氧化应激因子的关系

Relationships of blood glucose fluctuation with serum Omentin-1 and oxidative stress factors in patients with type 2 diabetes mellitus

    摘要
  • 摘要:
    目的 探讨2型糖尿病(T2DM)患者血糖波动与血清网膜素-1(Omentin-1)及氧化应激因子的关系。
    方法 选取134例T2DM患者为T2DM组, 另选取67例健康者为对照组。采用动态血糖监测系统(CGMS)对所有患者实施连续3 d的血糖跟踪检测。比较2组血糖波动参数日内平均血糖波动幅度(MAGE)、平均血糖标准差(SDBG)、日间血糖波动幅度(MODD)、最大血糖波动幅度(LAGE)、血清Omentin-1和氧化应激因子血清丙二醛(MDA)、超氧化物歧化酶(SOD)、8-异前列腺素F2α(8-iso-PGF2α)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GPX)、谷胱甘肽(GSH)、8-羟化脱氧鸟苷(8-OHDG)水平。根据MAGE的不同将T2DM组患者分为血糖平稳组(MAGE < 3.9 mmol/L)81例和血糖波动组(MAGE≥3.9 mmol/L)53例，比较2组血清Omentin-1和氧化应激因子水平。采用Pearson相关性分析探讨MAGE与血清Omentin-1和氧化应激因子的关系。
    结果 T2DM组MAGE、SDBG、MODD、LAGE、MDA、8-iso-PGF2α、8-OHDG水平均高于对照组, Omentin-1、SOD、CAT、GPX和GSH水平低于对照组，差异均有统计学意义(P < 0.01)。血糖波动组Omentin-1、SOD、CAT、GPX和GSH水平低于血糖平稳组，MDA、8-iso-PGF2α、8-OHDG水平高于血糖平稳组，差异均有统计学意义(P < 0.01)。Pearson相关性分析显示, MAGE与血清Omentin-1、SOD、CAT、GPX和GSH水平均呈负相关，与MDA、8-iso-PGF2α、8-OHDG水平均呈正相关(P < 0.05或P < 0.01)。
    结论 T2DM患者血糖波动较大，血糖波动与血清Omentin-1及氧化应激因子水平密切相关。

     

    Abstract:
    Objective To explore the relationships of blood glucose fluctuation with serum Omentin-1 and oxidative stress factors in patients with type 2 diabetes mellitus (T2DM).
    Methods A total of 134 patients with T2DM were selected as T2DM group, and 67 healthy people were selected as control group. A tracking detection of blood glucose in all the patients was conducted for 3 days by using continuous glucose monitoring system (CGMS). Levels of blood glucose fluctuation parametersdiurnal mean amplitude of glycemic excursions (MAGE), standard deviation of blood glucose (SDBG), mean of daily differences (MODD), the largest amplitude of glycemic excursions (LAGE), serum Omentin-1 and oxidative stress factorsserum malondialdehyde (MDA), superoxide dismutase (SOD), 8-iso-prostaglandin F2α (8-iso-PGF2α), catalase (CAT), glutathion peroxidase (GPX), glutathione (GSH), 8-hydroxylated deoxyguanosine (8-OHDG)were compared between the two groups. According to differed MAGE, T2DM patients were divided into glucose stabilization group (MAGE < 3.9 mmol/L) with 81 cases and glucose fluctuation group (MAGE≥3.9 mmol/L) with 53 cases, and levels of serum Omentin-1 and oxidative stress factors were compared between the two groups. The relationships of MAGE with serum Omentin-1 and oxidative stress factors were analyzed by Pearson correlation analysis.
    Results Levels of MAGE, SDBG, MODD, LAGE, MDA, 8-iso-PGF2α and 8-OHDG in the T2DM group were significantly higher than those in the control group, while the levels of Omentin-1, SOD, CAT, GPX and GSH were significantly lower than those in the control group (P < 0.01). Levels of Omentin-1, SOD, CAT, GPX and GSH in the glucose fluctuation group were significantly lower than those in the glucose stabilization group, while levels of MDA, 8-iso-PGF2α and 8-OHDG were significantly higher than those in the glucose stabilization group (P < 0.01). Pearson correlation analysis showed that MAGE was negatively correlated with levels of serum Omentin-1, SOD, CAT, GPX and GSH, while was positively correlated with levels of MDA, 8-iso-PGF2α and 8-OHDG (P < 0.05 or P < 0.01).
    Conclusion T2DM patients have significant glucose fluctuation, which is closely related to levels of serum Omentin-1 and oxidative stress factors.

     

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