Abstract:
Objective To investigate the levels of N-terminal probrain natriuretic peptide (NT-proBNP), thrombolomodulin (TM), C-type lectin-like receptor 2 (CLEC-2), galectin-3 (Gal-3) and their relationships with prognosis in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI).
Methods A total of 80 patients with ACS were selected as study objects. The patients were followed up for 6 months by outpatient visit or telephone follow-up, and the occurrence of major adverse cardiovascular events (MACE) was recorded in the patients. According to the occurrence of MACE, patients were divided into MACE group (26 cases) and control group (54 cases). The changes of serological indexes were compared between the two groups.
Results The expression levels of NT-proBNP, CLEC-2, TM and Gal-3 in serum of patients in the MACE group were significantly higher than those of control group (P < 0.05). Multivariate Logistic regression analysis showed that NT-proBNP, CLEC-2, TM, and Gal-3 were all influential factors for the occurrence of MACE after PCI in ACS patients (P < 0.05).
Conclusion NT-proBNP, CLEC-2, TM and Gal-3 are influencing factors for MACE in patients with ACS after PCI, and have a good predictive role in evaluating the occurrence of MACE.
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