亚精胺的神经保护作用及机制的研究进展

Research progress on neuroprotective effect and mechanism of spermidine

摘要: 亚精胺作为一种在神经细胞中含量较高的天然多胺, 在神经系统中有着调节突触可塑性、促进自噬、减轻氧化应激等作用。亚精胺及多胺代谢可能为神经系统损伤性疾病带来新的治疗思路。本研究围绕亚精胺在神经系统损伤性疾病中发挥的神经保护作用及机制展开综述。

Abstract: Spermidine, as a natural polyamine with high content in nerve cells, plays roles in regulating synaptic plasticity, promoting autophagy, and alleviating oxidative stress in the nervous system. Spermidine and polyamine metabolism may bring new therapeutic ideas for nervous system injury diseases. This paper reviewed the neuroprotective effects and mechanisms of spermidine in nervous system injury diseases.