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通心络胶囊对颈动脉支架植入术后再狭窄及血清炎症因子的影响

Effect of Tongxinluo Capsule on restenosis and serum inflammatory factors after carotid artery stenting

    摘要
  • 摘要:
    目的  探讨通心络胶囊对颈动脉支架植入术后再狭窄及血清炎症因子的影响。
    方法  将90例行颈动脉支架植入术的患者随机分为观察组和对照组, 每组45例。2组均给予常规治疗，观察组另给予通心络胶囊治疗。比较2组血清炎症因子C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平、血管内皮功能指标血管内皮生长因子(VEGF)、内皮素-1(ET-1)、一氧化氮(NO)、血流动力学指标颈动脉内膜中层厚度(IMT)、收缩期峰值血流速度(SV)、舒张期峰值血流速度(DV)、血管阻力指数(RI)、心脑血管事件发生率以及颈动脉支架植入术后再狭窄发生率。
    结果  治疗半年后，观察组CRP、TNF-α、IL-6水平均低于对照组，差异有统计学意义(P < 0.05); 观察组VEGF、ET-1水平低于对照组, NO水平高于对照组，差异有统计学意义(P < 0.05); 观察组IMT、RI水平低于对照组, SV、DV水平高于对照组，差异有统计学意义(P < 0.05)。观察组心脑血管事件发生率为4.44%, 对照组为13.33%, 差异无统计学意义(P > 0.05)。观察组术后再狭窄发生率为4.44%, 低于对照组的17.78%, 差异有统计学意义(P < 0.05)。
    结论  颈动脉支架植入术后应用通心络胶囊可延缓动脉粥样硬化进展，降低患者机体炎症反应程度，值得推广应用。

     

    Abstract:
    Objective  To explore the effects of Tongxinluo Capsule on restenosis and serum inflammatory factors after carotid artery stenting.
    Methods  A total of 90 patients with carotid artery stenting were randomly divided into observation group and control group, with 45 cases in each group. Both groups were conducted with conventional treatment, while the observation group was given additional Tongxinluo Capsule for treatment. The levels of serum inflammatory factors C reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), vascular endothelial function indexes vascular endothelial growth factor (VEGF), endothelin-1 (ET-1) and nitric oxide (NO), hemodynamics indexescarotid intima-media thickness (IMT), peak systolic blood flow velocity (SV), peak diastolic blood flow velocity (DV) and vascular resistance index (RI), incidence of cardiocerebral vascular events, and the incidence of restenosis after carotid artery stenting were compared between two groups.
    Results  After half a year of treatment, the levels of CRP, TNF-α and IL-6 in the observation group were significantly lower than those in the control group (P < 0.05); the levels of VEGF and ET-1 in the observation group were significantly lower than those in the control group, while the level of NO was significantly higher than that in the control group (P < 0.05); the levels of IMT and RI in the observation group were significantly lower than those in the control group, while the levels of SV and DV were significantly higher than those in the control group (P < 0.05). The incidence of cardiocerebral vascular events in the observation group was 4.44%, which showed no significant difference when compared to 13.33% in the control group (P > 0.05). The incidence of postoperative restenosis in the observation group was 4.44%, which was significantly lower than 17.78% in the control group (P < 0.05).
    Conclusion  The application of Tongxinluo Capsule after carotid artery stenting can delay the progression of atherosclerosis and reduce the degree of inflammatory reaction of patients, which is worthy of popularization and promotion.

     

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