Objective To explore the clinical value of transcranial Doppler examination (TCD) combined with C-shaped arm CT technique for prediction of acute ischemic cerebrovascular disease(ICVD) before intervention.

Methods Fifty-seven patients with acute ICVD were selected as the study objects. When all patients underwent interventional therapy, C-shaped arm CT technology and TCD were used to obtain images, and the examination results were recorded in detail. Digital subtraction angiography (DSA) was used as the "gold standard" to evaluate the clinical value of TCD combined with C-shaped arm CT before acute ICVD interventional therapy.

Results A total of 613 intracranial and extracranial vessels were detected by DSA in 57 patients with acute ICVD. DSA showed that there were 153 (24.96%) intracranial and extracranial stenosis or occlusion vessels and 460 (75.04%) normal extracranial vessels; compared with DSA gold standard, the positive prediction rate of C-shaped arm CT was 91.16% (134/147), that of TCD was 90.60% (135/149), and that of TCD combined with C-shaped arm CT was 90.42% (151/167). There were no significant differences in positive predictive value, specificity and accuracy between C-shaped arm CT, TCD and TCD combined with C-shaped arm CT (P>0.05); there was no significant difference in the negative predictive value and sensitivity of C-shaped arm CT and TCD (P>0.05); the negative predictive value and sensitivity of TCD combined with C-shaped arm CT were significantly higher than those of the C-shaped arm CT and TCD (P < 0.05).

Conclusion TCD combined with C-shaped arm CT technology has high clinical value in predicting acute ICVD patients before interventional therapy, and can effectively reduce the rate of missed diagnosis and has high diagnostic efficiency.