Abstract: Helicobacter pylori (H.pylori) infection is closely related to the occurrence and development of gastritis, gastrointestinal ulcer, gastric cancer and other gastrointestinal diseases. The molecular biological mechanism of H.pylori infection leading to the occurrence and development of gastric cancer is complex, which involves not only in transcriptional regulation, but also epigenetic and post-transcriptional regulations, and non-coding ribonucleic acid (RNA) plays an important role in H.pylori infection regulating oncogene expression and malignant biological behavior of cancer cells. At present, the widely studied non-coding RNAs include long chain non-coding RNA (lncRNA) and microRNA (miRNA). This paper reviewed the clinical and basic researches related to H.pylori infection regulating the expression of lncRNA and miRNA in the development of gastric cancer.