超声引导下经皮经肝胆管置管引流术治疗恶性梗阻性黄疸的效果观察

Effect of ultrasound-guided percutaneous transhepatic cholangial drainage in treatment of malignant obstructive jaundice

  • 摘要:
    目的 分析超声引导下经皮经肝胆管置管引流术(PTCD)治疗恶性梗阻性黄疸(MOJ)的效果。
    方法 收集38例超声引导下行PTCD治疗的MOJ患者的临床资料。比较术前与术后2周的血生化指标改善情况;根据梗阻性黄疸症状和胆红素水平改善情况评定疗效,计算总有效率;记录术后胆管出血、胆道感染、胆汁漏、引流管阻塞等并发症的发生率。
    结果 术后2周时,38例患者的总胆红素(TB)、丙氨酸氨基转氨酶(ALT)、直接胆红素(DB)、碱性磷酸酶(ALP)、γ-谷氨酰转肽酶(γ-GT)及血清清蛋白水平均较术前降低,差异均有统计学意义(P < 0.01)。38例患者在PTCD治疗2周后,总有效率为94.7%(36/38)。38例患者在接受PTCD治疗后,发生胆管出血1例,胆汁漏1例,胆道感染1例,并发症总发生率为7.9%(3/38)。
    结论 超声引导下PTCD治疗MOJ的操作安全,穿刺成功率高,能有效改善患者肝功能,有效缓解梗阻性黄疸症状,并且术后并发症发生率较低。

     

    Abstract:
    Objective To analyze the effect of ultrasound-guided percutaneous transhepatic cholangial drainage (PTCD) in the treatment of malignant obstructive jaundice (MOJ).
    Methods Clinical materials of 38 MOJ patients treated by ultrasound-guided PTCD were collected. The improvement of blood biochemical indexes before operation and 2 weeks after operation was compared; the curative effect was evaluated according to the symptoms of obstructive jaundice and the improvement of bilirubin level, and the total effective rate was calculated; the incidence rates of complications such as postoperative biliary bleeding, biliary infection, bile leakage and drainage tube obstruction were recorded.
    Results At 2 weeks after operation, levels of total bilirubin (TB), alanine aminotransferase (ALT), direct bilirubin (DB), alkaline phosphatase (ALP), γ-glutamyl transpeptidase (γ-GT) and serum albumin of patients were significantly lower than those before operation (P < 0.01). After 2 weeks of PTCD treatment in 38 patients, the total effective rate was 94.7% (36/38). After PTCD treatment in 38 patients, the total incidence of complications was 7.9% (3/38), including one case of bile duct bleeding, one case of bile leakage, and one case of biliary infection.
    Conclusion Ultrasound-guided PTCD is safe in the treatment of MOJ, with has a high success rate of puncture, which can effectively improve the patient's liver function, alleviate the symptoms of obstructive jaundice, and has a low postoperative incidence rate of complications.

     

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