Objective To observe the clinical efficacy of loperamide hydrochloride combined with Tongxiening Granules in the treatment of patients with diarrhea-predominant irritable bowel syndrome (IBS).

Methods Clinical materials of 60 patients with diarrhea-predominant IBS were collected, and they were divided into observation group (treated with loperamide hydrochloride and Tongxiening Granules) and control group (treated with loperamide hydrochloride only) according to different therapeutic methods, with 30 cases in each group. After 4 weeks of treatment, the abdominal pain score, diarrhea score and total symptom score before and after treatment were evaluated and compared between two groups.

Results Before treatment, there were no significant differences in the abdominal pain score, diarrhea score and total symptom score between the two groups (P>0.05); there were no significant differences in the abdominal pain score, diarrhea score and total symptom score before and after treatment in the control group (P>0.05); after treatment, the abdominal pain score, diarrhea score and total symptom score were significantly lower than those before treatment in the observation group, and these indexes in the observation were also significantly lower than those in the control group (P < 0.05). During the medication, no obvious adverse reactions were observed in both groups.

Conclusion Loperamide hydrochloride combined with Tongxiening Granules is effective in the treatment of patients with diarrhea-predominant IBS, and the safety of medication is good.