Abstract: Helicobacter pylori (Hp) is a Gram-negative bacterium that mainly colonizes the stomach and duodenum, which can cause gastritis, peptic ulcer and gastric cancer. Antibiotics are the main therapeutic drugs for eradicating Hp at present. However, but with the widely application of antibiotics, the drug resistance of Hp is also increasing year by year. This paper reviewed the mutation sites of resistance genes in the commonly used antibiotics for Hp, the new detection methods and therapeutic drugs, in order to provide reference for eradicating Hp, selecting sensitive antibiotics and formulating individualized therapy.