Objective  To observe the clinical effect of vortioxetine combined with mindfulness decompression in the treatment of patients with acute post-traumatic stress disorder.

Methods  A total of 118 patients with acute post-traumatic stress disorder were selected and randomly divided into observation group and control group, with 59 cases in each group. The observation group was treated with vortioxetine and mindfulness decompression, while the control group was treated with mindfulness decompression and placebo.

Results  The total effective rate of the observation group was 91.53%(54/59), which was significantly higher than 76.27% (45/59) of the control group (P < 0.05). After treatment, the scores of tenacity, strength, optimism and total score of the Connor-Davidson Resilience Scale (CD-RISC) in the observation group were higher than those in the control group; the levels of calmodulin (CaM), adrenocorticotropic hormone (ACTH) and human tartrate resistant acid phosphatase (TRAP) in the observation group were lower than those in the control group; the levels of 8-hydroxydeoxyguanosine (8-OHdG) and myeloperoxidase (MPO) in the observation group were significantly lower than those in the control group, while the level of glutathione peroxidase (GSH-Px) was significantly higher than that in the control group (P < 0.05). The incidence rate of adverse reactions was 13.56% (8/59) in the observation group and 8.47%(5/59) in the control group, and there was no significant difference between two groups (P>0.05).

Conclusion  Vortioxetine combined with mindfulness decompression is effective in the treatment of patients with acute post-traumatic stress disorder, which can improve psychological resilience, and reduce the level of inflammatory reaction and oxidative stress of patients.