Objective To explore the effects of immune-enhancing food and activity program on immunologic function and inflammatory factors in human papillomavirus (HPV) infected women.

Methods A total of 184 high-risk HPV infection patients who were diagnosed and treated in our hospital were selected. According to the random number table method, they were divided into immunity-enhancing group and routine intervention group, with 92 cases in each group. The routine intervention group adopted the routine management mode to carry out HPV infection-related diseases and knowledge health education program; on the basis of the routine intervention group, the patients in the immune-improving group were given immune-improving therapy(intensive diet management combined with exercise guidance program). The levels of serum immunoglobulin and inflammatory factors related indexes in the two groups were observed before and after treatment, and the self-efficacy score and clinical efficacy of the two groups were compared, and the correlation between the self-efficacy score and clinical efficacy was analyzed.

Results After treatment, the levels of serum immunoglobulin in the two groups decreased significantly than treatment before, and the indexes levels in the immune-enhancing group decreased more significantly than the routine intervention group (P < 0.05). After treatment, serum interleukin (IL)-2 levels in the two groups were significantly increased, and the level of IL-2 in the immune-enhancing intervention group increased significantly than the routine intervention group (P < 0.05). After treatment, serum IL-4 and IL-10 levels in the two groups were significantly decreased, and were lower in the immunity-enhancing group those in the routine intervention group (P < 0.05). After treatment, self-efficacy including self-cognition, treatment environment, disease control, self-confidence score and total score in the immune-enhancing group were higher than those in routine intervention group (P < 0.05). Spearman correlation coefficient analysis showed that self-efficacy score of HPV infected patients was significantly positively correlated with clinical efficacy (P < 0.05).

Conclusion The application of immune-enhancing diet and activity program in patients with HPV infection has positive effects in improving clinical effective rate, self-efficacy, immune function and relieving inflammatory response.