Abstract: E4 promoter-binding protein 4 (E4BP4) is a transcription factor containing alkaline leucine zips, which is highly expressed in breast cancer, lung cancer, thyroid cancer, colorectal cancer and other malignant tumors, and is involved in the occurrence, development, metastasis and invasion of tumors. However, there are few reviews on E4BP4 in tumor research. In this paper, relevant literature was searched and summarized, and the role of E4BP4 in the occurrence and development of different tumors was summarized, so as to provide theoretical support for further study of the mechanism of action of E4BP4 in tumors and exploration of therapeutic targets based on E4BP4 molecules.