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生精胶囊(片)治疗少弱精子症有效性的Meta分析

Meta-analysis of efficacy of Shengjing Capsules (Tablets) in the treatment of oligoasthenospermia

    摘要
  • 摘要:
    目的 系统评价生精胶囊（片）治疗少弱精子症的有效性。
    方法 应用计算机检索中国学术期刊全文数据库（CNKI）、万方数据知识服务平台（Wanfang Data）、维普中文期刊全文数据库（VIP）、循证医学图书馆（The Cochrane Library）、美国生物医学期刊文献数据库（PubMed）中生精胶囊（片）治疗少弱精子症的随机对照试验（RCT）文献，检索时限为自建库至2022年8月9日。由2名研究人员按照检索方式进行文献查阅，并对文献进行纳入和排除的筛选。使用RevMan 5.4软件进行Meta分析。
    结果 共纳入26篇文献，累计2 902例样本。Meta分析结果显示，采用生精胶囊（片）治疗的试验组总有效率高于对照组（RR=1.41，95%CI：1.25~1.60，P < 0.000 01），在改善患者精液量（MD=0.50，95%CI：0.30~0.71，P < 0.000 01）、精液密度（MD=12.39，95%CI：9.19~15.59，P < 0.000 01）、a级精子率（MD=7.24，95%CI：4.39~10.08，P < 0.000 01）、（a+b）级精子率（MD=9.00，95%CI：3.25~18.15，P < 0.000 01）方面均优于对照组。
    结论 本文Meta分析研究显示生精胶囊（片）治疗少弱精子症疗效较好，但仍需更多高质量、大样本的RCT提供高级别的循证医学数据。

     

    Abstract:
    Objective To systematically review the effectiveness of Shengjing Capsules (Tablets) in the treatment of oligoasthenozoospermia.
    Methods The random controlled trials (RCT) of Shengjing Capsules (Tablets) in treating oligoasthenospermia in China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform (Wanfang Data), China Science and Technology Journal Database(VIP), the Cochrane Library and PubMed were searched by computers, and the search time was from the establishment of the database to August 9, 2022. Literature review was conducted by two researchers according to the search methods, and the literatures were screened for inclusion and exclusion. RevMan 5.4 software was used for meta-analysis.
    Results A total of 26 literatures were included, with a total of 2 902 samples. Meta-analysis result show that the total effective rate of trail group treated with Shengjing Capsules (Tablets) was significantly higher than that of the control group(RR=1.41, 95%CI, 1.25 to 1.60, P < 0.000 01), and the improvementsin semen volume (MD=0.50, 95%CI, 0.30 to 0.71, P < 0.000 01), semen density(MD=12.39, 95%CI, 9.19 to15.59, P < 0.000 01), sperm rate ofgrade a (MD=7.24, 95%CI, 4.39 to 10.08, P < 0.000 01) and sperm rate of gradea plus b(MD=9.00, 95%CI, 3.25 to 18.15, P < 0.000 01) were significantly better than those of the control group.
    Conclusion Meta-analysis study shows that Shengjing Capsules (Tablets) is effective in the treatment of oligoasthenospermia, but we still need more RCTs with high quality and large samples to provide high-level evidence-based medical data.

     

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