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促炎性因子、氧化应激指标在低龄患儿化脓性脑膜炎中的表达

Expression of pro-inflammatory factors and oxidative stress index in young children with suppurative meningitis

    摘要
  • 摘要:
    目的  探讨促炎性因子、氧化应激指标在低龄化脓性脑膜炎(PM)患儿中的表达及临床意义。
    方法  回顾性分析60例PM患儿的临床资料，根据其疾病进展程度分为普通PM组36例与重症PM组24例，另选取同期诊治的50例非中枢感染性疾病患儿作为对照组。比较3组患儿脑脊液中促炎性因子肿瘤坏死因子-α(TNF-α)、巨噬细胞炎症蛋白-1α(MIP-1α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及氧化应激指标超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)的水平。采用Spearman相关性分析法分析相关指标水平与PM患儿病情严重程度的关系。
    结果  重症PM组、普通PM组IL-6水平高于对照组，差异有统计学意义(P < 0.05)。重症PM组、普通PM组的TNF-α、IL-8水平均高于对照组，且重症PM组高于普通PM组，差异有统计学意义(P < 0.05)。重症PM组、普通PM组MDA、NO水平均高于对照组，且重症PM组高于普通PM组，差异有统计学意义(P < 0.05)。重症PM组、普通PM组SOD水平均高于对照组，差异有统计学意义(P < 0.05)。PM病情严重程度与TNF-α(r=0.354)、IL-8(r=0.397)、MDA(r=0.437)、NO(r=0.456)水平均呈正相关(P < 0.05或P < 0.01)。
    结论  PM患儿疾病进展与促炎性因子水平及氧化应激反应有关。临床可依据上述指标对PM患儿疾病进行诊治。

     

    Abstract:
    Objective  To explore the expression and clinical significance of pro-inflammatory factors and oxidative stress indicators in young children with purulent meningitis (PM).
    Methods  Clinical data of 60 children with PM were retrospectively analyzed, and they were divided into normal PM group (36 cases) and severe PM group (24 cases) according to the degree of disease progression. Another 50 children with non-central infectious diseases were selected as control group. The levels of proinflammatory factors tumor necrosis factor-α (TNF-α), macrophagic inflammatory protein-1α (MIP-1α), interleukin-6 (IL-6) and interleukin-8 (IL-8) and oxidative stress indexes superoxide dismutase (SOD), malondialdehyde (MDA) and nitrogen monoxide (NO) in cerebrospinal fluid of the three groups were compared. Spearman correlation analysis was used to analyze the relationship between the level of related indicators and the severity of PM children.
    Results  The IL-6 levels in the severe PM group and normal PM group were significantly higher than that in the control group (P < 0.05). The levels of TNF-α and IL-8 in the severe PM group and the normal PM group were significantly higher than those in the control group, and the severe PM group was significantly higher than that in the normal PM group (P < 0.05). The levels of MDA and NO in the severe PM group and the normal PM group were significantly higher than those in the control group, and the severe PM group was significantly higher than that in the normal PM group (P < 0.05). The SOD levels of the severe PM group and normal PM group were significantly higher than those of the control group (P < 0.05). The severity of PM disease was positively correlated with the levels of TNF-α (r=0.354), IL-8 (r=0.397), MDA (r=0.437) and NO (r=0.456) (P < 0.05 or P < 0.01).
    Conclusion  Disease progression in children with PM is related to the level of proinflammatory cytokines and oxidative stress response. Clinical diagnosis and treatment of PM children can be based on the above indicators.

     

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