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长链非编码RNA TMEVPG1在原发性免疫性血小板减少症患者预后评估中的价值

Value of long non-coding RNA TMEVPG1 in prognosis evaluation of patients with primary immune thrombocytopenia

    摘要
  • 摘要:
    目的 探讨长链非编码RNA(lncRNA) TMEVPG1在原发性免疫性血小板减少症(ITP)患者预后评估中的价值。
    方法 选取126例ITP患者作为研究组，根据ITP患者预后情况分为预后不良组31例和预后良好组95例，另选取同期体检的125例健康者作为对照组。采用实时荧光定量PCR(qRT-PCR)测定lncRNA TMEVPG1相对表达量; 采用Pearson法分析ITP患者lncRNA TMEVPG1与血小板计数、干扰素-γ(IFN-γ)、白细胞介素(IL)-2、IL-4、IL-10的相关性; 采用COX回归分析探讨影响ITP患者预后的有关因素。
    结果 与对照组比较，研究组患者lncRNA TMEVPG1水平降低，差异有统计学意义(P < 0.05); 预后不良组患者lncRNA TMEVPG1水平低于预后良好组，差异有统计学意义(P < 0.05)。lncRNA TMEVPG1与血小板计数、IL-4、IL-10呈正相关，与IFN-γ、IL-2呈负相关(P < 0.05); lncRNA TMEVPG1降低是ITP患者预后不良的独立危险因素(P < 0.05)。
    结论 LncRNA TMEVPG1水平降低与ITP患者预后不良有关，其可作为ITP患者预后评估的辅助指标。

     

    Abstract:
    Objective To investigate the value of long non-coding RNA (lncRNA) TMEVPG1 in the prognosis evaluation of patients with primary immune thrombocytopenia (ITP).
    Methods A total of 126 ITP patients were selected as the study group. According to the prognosis of ITP patients, they were divided into poor prognosis group (n=31) and good prognosis group (n=95), and 125 healthy subjects who underwent physical examination during the same period were selected as control group. The relative expression level of lncRNA TMEVPG1 was determined by quantitative real-time polymerase chain reaction (qRT-PCR); correlations of lncRNA TMEVPG1 with platelet count, interferon-γ (IFN-γ), interleukin (IL)-2, IL-4 and IL-10 in ITP patients were explored by Pearson correlation; the factors influencing the prognosis of ITP patients were analyzed by COX regression.
    Results Compared with the control group, lncRNA TMEVPG1 level in the study group was significantly decreased (P < 0.05); lncRNA TMEVPG1 level in the poor prognosis group was significantly lower than that in the good prognosis group (P < 0.05). LncRNA TMEVPG1 was positively correlated with platelet count, IL-4 and IL-10, and negatively correlated with IFN-γ and IL-2 (P < 0.05). Lower lncRNA TMEVPG1 was an independent risk factor for poor prognosis in ITP patients (P < 0.05).
    Conclusion The decreased level of LncRNA TMEVPG1 is associated with poor prognosis in ITP patients, which can be used as an auxiliary indicator to evaluate the prognosis of ITP patients.

     

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