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血清25-羟维生素D和脂联素与脑白质损伤患者认知功能的相关性研究

Correlations of serum 25-hydroxyvitamin D and adiponectin with cognitive function in patients with white matter lesions

    摘要
  • 摘要:
    目的 探讨血清25-羟维生素D25(OH)D、脂联素水平与脑白质损伤(WML)患者认知功能的关系。
    方法 选取112例WML患者作为研究对象，根据蒙特利尔认知评估量表(MoCA)评分将其分为认知正常组(MoCA评分≥26分)45例和认知障碍组(MoCA评分 < 26分)67例。比较2组患者的一般资料和25(OH)D、脂联素等实验室检查指标水平，分析认知障碍组患者血清25(OH)D、脂联素水平与MoCA评分的相关性，通过二元Logistic回归分析探讨WML患者发生认知功能障碍的影响因素。
    结果 认知障碍组年龄、合并高血压病者占比、同型半胱氨酸水平高于认知正常组，差异有统计学意义(P < 0.05); 认知障碍组25(OH)D、脂联素水平分别为(16.47±5.05) ng/mL、6.54(5.72, 8.17) mg/L，低于认知正常组的(21.08±5.46) ng/mL、9.40(7.48, 10.53) mg/L, 差异有统计学意义(P < 0.05); 2组性别、文化程度、吸烟史、饮酒史、合并糖尿病情况以及总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、空腹血糖、尿酸、肌酐水平比较，差异均无统计学意义(P>0.05)。Spearman相关性分析结果显示，认知障碍组患者血清25(OH)D、脂联素水平均与MoCA评分呈正相关(r=0.732、0.534, P < 0.001)。二元Logistic回归分析结果显示，年龄、同型半胱氨酸水平、25(OH)D水平、脂联素水平为WML患者发生认知功能障碍的影响因素(P < 0.05)。
    结论 血清25(OH)D、脂联素与WML患者发生认知功能障碍有关，或可成为WML患者认知功能障碍的预测因子。

     

    Abstract:
    Objective To explore the correlations of serum 25-hydroxyvitamin D25(OH)D, adiponectin with cognitive function in patients with white matter lesions(WML).
    Methods A total of 112 patients with WML were enrolled as study objects. WML patients were divided into normal cognition group (MoCA score≥26, 45 cases) and cognitive impairment group (MoCA score < 26, 67 cases) according to the score of the Montreal Cognitive Assessment Scale(MoCA). The general data, laboratory examination index levels such as 25 (OH) D, adiponectin of the two groups were compared. The correlations of serum 25(OH)D and adiponectin with MoCA score in the cognitive impairment group were analyzed, and the influencing factors of cognitive impairment in WML patients were analyzed by binary Logistic regression.
    Results The age, proportion of patients with hypertension and homocysteine level in the cognitive impairment group were higher than those in the normal cognition group, and the differences were statistically significant(P < 0.05). The levels of 25(OH)D and adiponectin in the cognitive impairment group were (16.47±5.05) ng/mL and 6.54(5.72, 8.17) mg/L, respectively, which were lower than (21.08±5.46) ng/mL and 9.40 (7.48, 10.53) mg/L, respectively in the normal cognition group, and the differences were statistically significant (P < 0.05). There were no significant differences in gender, education level, smoking history, drinking history, complicating with diabetes mellitus, total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, fasting blood glucose, uric acid and creatinine levels between the two groups (P>0.05). Spearman correlation analysis showed that serum 25(OH)D and adiponectin level were positively correlated with MoCA score in cognitive impairment group (r=0.732, 0.534, P < 0.001). Binary Logistic regression results showed that age, homocysteine, 25(OH)D level and adiponectin were the influencing factors of cognitive impairment in WML patients.
    Conclusion Serum 25(OH)D and adiponectin are related to cognitive impairment and may be its predictive factors of patients with WML.

     

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