Objective To explore the relationships of serum homocysteine (Hcy), serum soluble interleukin 2 receptor (SIL-2R) levels with Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) scores in acute pancreatitis (AP) patients.

Methods A total of 82 AP patients were selected as AP group, and 66 healthy subjects were selected as control group. Serum levels of Hcy and sIL-2R were compared between the two groups. According to APACHE Ⅱ score, they were divided into mild AP group (MAP group, n=50, APACHE Ⅱ score < 8), severe AP group (SAP group, n=32, APACHE Ⅱ score ≥ 8). The correlations of Hcy and SIL-2R with APACHE Ⅱ score were analyzed by Pearson method.

Results The levels of serum Hcy and SIL-2R in the AP group were (10.75±2.05) mmol/L, (39.46±8.12) pg/mL, respectively, which were significantly higher than (6.02±0.37) mmol/L and (14.51±3.64) pg/mL in the control group (P < 0.05). Serum Hcy and SIL-2R levels and APACHE Ⅱ score in the SAP group were (15.93±0.37) mmol/L (51.32±11.09) pg/mL and (16.74±3.11) points, which were higher than (7.44±1.12) mmol/L, (31.87±6.58) pg/mL and (4.11±0.64) points in the MAP group (P < 0.05). Correlation analysis showed that serum Hcy, sIL-2R were positively correlated with APACHE Ⅱ score (P < 0.05).

Conclusion Serum Hcy and sIL-2R are highly expressed in AP patients, and have a certain correlation with the APACHE Ⅱ score, which are expected to become auxiliary indicators for predicting the severity of AP patients.