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血清干扰素-γ、淀粉样蛋白A及可溶性血管内皮生长因子受体-1在原因不明复发性流产患者中的表达及意义

Expression and significance of serum interferon-γ, serum amyloid A protein and soluble fms-like tyrosine kinase-1 in patients with unexplained recurrent spontaneous abortion

    摘要
  • 摘要:
      目的  探讨血清干扰素-γ(IFN-γ)、血清淀粉样蛋白A(SAA)及可溶性血管内皮生长因子受体-1(sFlt-1)在原因不明复发性流产(URSA)患者中的表达及意义。
      方法  前瞻性选取URSA患者100例为研究组，另选取同期行人工流产的正常早孕妇女60例为对照组。2组均进行血清IFN-γ、SAA及sFlt-1检测。比较2组血清IFN-γ、SAA及sFlt-1表达。采用受试者工作特征(ROC)曲线分析血清IFN-γ、SAA及sFlt-1对URSA的预测价值。
      结果  2组年龄、分娩次数及自然流产次数比较，差异有统计学意义(P<0.05)。研究组血清IFN-γ、SAA及sFlt-1水平高于对照组，差异有统计学意义(P<0.05)。血清IFN-γ与SAA、sFlt-1均呈正相关(r=0.671、0.728, P<0.05); SAA与sFlt-1呈正相关(r=0.708, P<0.05)。年龄、IFN-γ、SAA、sFlt-1为URSA发生的影响因素(P<0.05)。ROC曲线结果显示，血清IFN-γ、SAA及sFlt-1预测URSA的曲线下面积(AUC)为0.877、0.862、0.850; 血清IFN-γ预测URSA的敏感度为80.0%、特异度为85.0%, SAA敏感度为78.0%、特异度为88.3%, sFlt-1敏感度为70.0%、特异度90.0%。
      结论  血清IFN-γ、SAA及sFlt-1水平升高为URSA的危险因素，且对URSA具有一定预测价值。

     

    Abstract:
      Objective  To investigate the expression and significance of serum interferon-γ (IFN-γ), serum amyloid A (SAA) and soluble fms-like tyrosine kinase-1 (sFlt-1) in patients with unexplained recurrent spontaneous abortion (URSA).
      Methods  A total of 100 URSA patients were prospectively selected as study group, and 60 normal early pregnant women who underwent artificial abortion during the same period were selected as control group. Serum IFN-γ, SAA and sFlt-1 were detected in both groups, the expressions of serum IFN-γ, SAA and sFlt-1 were compared between the two groups. Receiver operator characteristic (ROC) curve was used to analyze the predictive value of serum IFN-γ, SAA and sFlt-1 in URSA patients.
      Results  There were significant differences in age, number of deliveries and number of spontaneous abortion between the two groups (P<0.05). The levels of serum IFN-γ, SAA and sFlt-1 in the study group were significantly higher than those in the control group (P<0.05). Serum IFN-γ was positively correlated with SAA and sFlt-1 (r=0.671, 0.728, P<0.05); SAA was positively correlated with sFlt-1 (r=0.708, P<0.05). Age, IFN-γ, SAA and sFlt-1 were the influencing factors of URSA occurrence (P<0.05). ROC results showed that the area under the curve (AUC) of serum IFN-γ, SAA and sFlt-1 for predicting URSA were 0.877, 0.862 and 0.850. The sensitivity and specificity of serum IFN-γ were 80.0% and 85.0% respectively. The sensitivity and specificity of SAA were 78.0% and 88.3% respectively. The sensitivity and specificity of sFlt-1 were 70.0% and 90.0% respectively.
      Conclusion  Increased serum IFN-γ, SAA and sFlt-1 levels are the risk factors for URSA, and have certain predictive value for URSA.

     

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