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精神分裂症不同阶段的血管内皮生长因子和炎症标记物水平比较

Comparison of vascular endothelial growth factor and inflammatory markers in different stages of schizophrenia

    摘要
  • 摘要:
    目的 比较精神分裂症患者复发期和缓解期的炎症标志物、血管内皮生长因子(VEGF)水平。
    方法 选取65例缓解期精神分裂症患者、45例复发期精神分裂症患者分别纳入缓解期组、复发期组，另选取58名健康受试者纳入对照组，检测并比较3组研究对象的炎症标记物白细胞、中性粒细胞、血小板、淋巴细胞、单核细胞、中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、单核细胞与淋巴细胞比值(MLR)和VEGF水平。
    结果 复发期组中性粒细胞、血小板、单核细胞、NLR、PLR和MLR水平高于对照组，淋巴细胞水平低于对照组，差异有统计学意义(P < 0.05); 缓解期组MLR、PLR水平高于对照组，中性粒细胞、淋巴细胞水平低于对照组，差异有统计学意义(P < 0.05); 3组白细胞水平比较，差异无统计学意义(P>0.05)。复发期组中性粒细胞、单核细胞、NLR、PLR和MLR水平均高于缓解期组，淋巴细胞水平低于缓解期组，差异有统计学意义(P < 0.05); 复发期组血小板水平与缓解期组比较，差异无统计学意义(P>0.05)。复发期组患者VEGF水平为(351.62±121.84) pg/mL, 低于缓解期组的(422.83±130.53) pg/mL, 差异有统计学意义(P < 0.05); 对照组VEGF水平为(438.64±213.80) pg/mL, 与缓解期组比较，差异无统计学意义(P>0.05)。
    结论 炎性标记物、VEGF异常是精神分裂症患者病情复发的重要标志，支持精神分裂症的炎症假说和神经营养假说。

     

    Abstract:
    Objective To compare the levels of inflammatory markers and vascular endothelial growth factor (VEGF) in patients with schizophrenia during relapse and remission stages.
    Methods A total of 65 patients with schizophrenia in remission and 45 patients with schizophrenia inrelapse were included in remission stage group and relapse stage group. Another 58 healthy subjects were included in control group. Inflammatory markers white blood cell, neutrophil, platelet, lymphocyte, monocyte, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR)and VEGF levels were measured and compared among the three groups.
    Results Compared with the control group, the levels of neutrophils, platelets, monocytes, NLR, PLR and MLR in the relapse stage group were higher, while the level of lymphocytes was lower, the differences were statistically significant(P < 0.05). The levels of MLR and PLR in the remission stage group were higher than those in the control group, while the levels of neutrophils and lymphocytes were lower than those in the control group (P < 0.05). There was no significant difference in white blood cell level among the three groups (P>0.05). The levels of neutrophils, monocytes, NLR, PLR and MLR in the relapse stage group were higher than those in the remission stage group, while the level of lymphocytes was lower than those in the remission stage group (P < 0.05). There was no significant difference in platelet level between the relapse stage group and the remission stage group (P>0.05). VEGF level in the relapse stage group was (351.62±121.84) pg/mL, which was lower than (422.83±130.53) pg/mL in the remission stage (P < 0.05). The VEGF level in the control group was (438.64±213.80) pg/mL, and there was no significant difference compared with that in the remission stage group (P>0.05).
    Conclusion Abnormal inflammatory factors and VEGF are important markers of relapse in patients with schizophrenia, supporting the inflammation and neurotrophichypothesis relating schizophrenia.

     

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