Abstract: Main histopathological features of psoriasis vulgaris are epidermal proliferation, dermal inflammatory cell infiltration, neovascularization and the formation of Munro's microabscesses, and its mechanism is closely related to the related signal pathways. Abnormal expression of upstream signal molecules such as miRNA and cytokines of mitogen activated protein kinase (MAPK) signal pathway leads to abnormal activation of downstream signal molecules, which plays an important role in the pathogenesis of psoriasis, and is expected to become a new intervention target. The article reviewed the research progress of MAPK signaling pathway in the pathogenesis of psoriasis vulgaris, so as to provide reference for drug development and precision treatment.