Objective To analyze the value of plasma cathepsin S (Cat S) and thrombospondin-1 (TSP-1) in early diagnosis of neonatal disseminated intravascular coagulation (DIC).

Methods Fifty DIC neonate patients were selected as DIC group, and 48 neonates with normal coagulation function during the same period were selected as control group. The plasma Cat S, TSP-1 and coagulation function levels of neonates in the two groups were compared, and the correlations of the levels of plasma Cat S, TSP-1 and coagulation function indexes with occurrence of neonatal DIC were analyzed, and their diagnostic efficacy for neonatal DIC was observed.

Results Before treatment, levels of plasma Cat S, TSP-1, D-dimer (D-D), activated partial thrombin time (APTT) and prothrombin time (PT) were higher and longer than those in the control group, while platelet (PLT) level in the DIC group was lower than those in the control group, the differences were statistically significant (P < 0.05). After treatment, the levels of plasma Cat S, TSP-1, APTT, PT and D-D in the DIC group were lower than before treatment (P < 0.05); the plasma Cat S, TSP-1, APTT, PT and D-D were positively correlated with occurrence of neonatal DIC, and PLT was negatively correlated with DIC in neonates (P < 0.001).

Conclusion Plasma Cat S and TSP-1 have a certain diagnostic value for neonatal DIC. The combination of Cat S and TSP-1 has high diagnostic efficiency.