阜阳市丙型病毒性肝炎流行病学特点及疾病进展影响因素

Epidemiological characteristics of viral hepatitis C in Fuyang city and influencing factors of disease progression

  • 摘要:
    目的 探讨2019—2020年阜阳市丙型病毒性肝炎(简称丙肝)的流行病学特点及疾病进展影响因素。
    方法 选取丙肝患者280例为研究对象,根据疾病进展情况分为慢性肝炎组(n=158)、代偿期肝硬化组(n=41)和失代偿期肝硬化组(n=81)。采用描述流行病学方法分析丙肝患者流行病学特点; 分析患者疾病进展的可能相关因素。
    结果 280例丙肝患者中,男161例,女119例,发病年龄集中在40~60岁; 62.50%患者分布在农村; 61.79%患者具有血液接触史; 患者职业主要为农民。基因分型1b型和2a型、丙氨酸氨基转移酶(ALT)、病毒定量、持续病毒学应答(SVR)率、合并症是丙肝疾病进展的影响因素(P<0.05)。
    结论 2019—2020年阜阳市丙肝患者中男性占比略高于女性,农村居民占比高于城市。阜阳市丙肝患者疾病进展影响因素较多,应结合本市流行病学特点进行干预,以降低肝失代偿和肝硬化发生率。

     

    Abstract:
    Objective To investigate the epidemiological characteristics of viral hepatitis C in Fuyang city and its influencing factors of disease progression from 2019 to 2020.
    Methods A total of 280 patients with viral hepatitis C were selected as study objects, and divided into chronic hepatitis group (n=158), compensatory cirrhosis group (n=41) and decompensated cirrhosis group (n=81) according to disease progression. The epidemiological characteristics of viral hepatitis C patients were analyzed by descriptive epidemiological method; possible factors associated with disease progression in patients were analyzed.
    Results Among the 280 patients with viral hepatitis C, 161 were males and 119 were females, and the onset age was mainly from 40 to 60 years; the 62.50% of the patients were in rural areas; the 61.79% patients had a history of blood contact; the patients were mainly farmers. Genotype 1b and 2a, alanine aminotransferase (ALT), virus quantitative, sustained virological response (SVR) rate and complication were influencing factors for the development of viral hepatitis C (P < 0.05).
    Conclusion From 2019 to 2020, the incidence rate of viral hepatitis C in Fuyang city is slightly higher in males than females, and its incidence rate in patients living rural areas is higher than that in urban areas. There are many factors influencing the disease progression of viral hepatitis C patients in Fuyang city, they should be intervened combined with the epidemiological characteristics of the city in order to reduce the incidence of liver decompensation and cirrhosis.

     

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