Abstract: Pancreatic cancer is a common malignant tumor of the digestive system. It is discovered late, has a high degree of malignancy, and has an extremely poor prognosis. The treatment of pancreatic cancer includes surgical resection, chemotherapy, and radiotherapy. Due to its low surgical resection rate and poor sensitivity to chemical and radiotherapy, it leads to a low 5-year survival rate. As a new type of treatment, immunotherapy is used to treat some malignant solid tumors in combination with other treatments, and a certain degree of partial remission has been obtained. After the downgrading, the chance of surgery is obtained and the overall survival of the patient is prolonged, and it brings hope for the comprehensive treatment of pancreatic cancer. This article reviewed the research progress and current situation of pancreatic cancer immunotherapy and other treatment methods, and provided reference for the treatment of pancreatic cancer.