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加味升陷汤联合常规治疗对射血分数保留型心力衰竭患者的疗效

Efficacy of Jiawei Shengxian Decoction combined with conventional treatment in patients with ejection fraction reserved heart failure

    摘要
  • 摘要:
    目的 观察加味升陷汤对射血分数保留型心力衰竭(HFpEF)患者的治疗效果。
    方法 选择60例HFpEF患者(气虚血瘀型)为研究对象, 随机分为试验组及对照组, 每组30例。对照组予以常规西医治疗, 试验组在对照组基础上配合加味升陷汤口服, 治疗时间为12周。观察2组治疗前后中医症状积分、6 min步行试验(6MWT)以及N-末端脑钠肽原(NT-ProBNP)的变化。
    结果 试验组和对照组治疗后胸闷气喘、水肿、心悸、倦怠懒言、自汗、气短症状积分比较, 差异有统计学意义(P < 0.05或P < 0.01)。2组患者治疗后中医症状总积分均降低, 但试验组中医症状总积分降低程度更大, 差异有统计学意义(P < 0.01)。治疗后, 2组患者6MWT提升, 且试验组6MWT高于对照组, 差异有统计学意义(P < 0.05或P < 0.01)。治疗后, 2组患者NT-ProBNP下降, 且试验组NT-ProBNP下降幅度大于对照组, 差异有统计学意义(P < 0.05或P < 0.01)。
    结论 加味升陷汤对HFpEF患者治疗效果较好, 能够调整人体脏腑和气血功能, 有效改善HFpEF患者的临床症状及心功能, 是一种有效的治疗方法。

     

    Abstract:
    Objective To observe effect of Jiawei Shengxian Decoction in patients with heart failure with preserved ejection fraction (HFpEF).
    Methods A total of 60 HFpEF patients with qideficiency and blood stasis were selected as study objects, and were randomly divided into experimental group and control group, with 30 cases in each group.The control group was given conventional western medicine treatment, and the experimental group was orally administrated with Jiawei Shengxian Decoction on the basis of the control group.The treatment duration was 12 weeks.The scores of TCM symptoms, 6-minute walking test (6MWT) and changes of N-terminal brain natriuretic peptide (NT-ProBNP) were observed before and after treatment in two groups.
    Results Scores of symptoms of chest tightness and panting, edema, palpitation, fatigue and laziness to speak, spontaneous sweating and shortness of breath between experimental group and control group (P < 0.05 or P < 0.01).The total score of TCM symptoms in two groups after treatment was reduced, but the total score of TCM symptoms in the experimental group decreased more significantly (P < 0.01).After treatment, 6MWT of the two groups was significantly increased, and 6MWT of the experimental group was significantly higher than that of the control group (P < 0.05 or P < 0.01).After treatment, NT-ProBNP in two groups was significantly decreased, and the decrease of NT-ProBNP in the experimental group was greater than that in the control group (P < 0.05 or P < 0.01).
    Conclusion Jiawei Shengxian Decoction has better therapeutic effect in HFpEF patients, it can adjust the functions of viscera, qi and blood, effectively improve the clinical symptoms and heart function of patients with HFpEF, and is an effective treatment.

     

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