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环磷腺苷葡胺联合单硝酸异山梨酯治疗慢性心力衰竭患者的效果分析

Analysis of efficacy of meglumine adenosine cyclophosphate combined with isosorbide mononitrate for patients with chronic heart failure

    摘要
  • 摘要:
    目的 探讨环磷腺苷葡胺联合单硝酸异山梨酯对慢性心力衰竭(CHF)患者的治疗效果。
    方法 选取92例CHF患者为研究对象, 随机分为对照组和研究组, 每组46例。对照组给予环磷腺苷葡胺治疗, 研究组在对照组基础上联合单硝酸异山梨酯治疗。观察2组临床疗效、左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)、左心室射血分数(LVEF)、心输出量(CO)、N末端脑钠肽前体(NT-proBNP)及胰岛素生长因子-1(IGF-1)、肌钙蛋白T (cTnT)水平。
    结果 研究组总有效率为95.65%, 高于对照组的76.09%, 差异有统计学意义(P < 0.05)。治疗后, 2组LVEDV、LVESV、NT-proBNP和cTnT水平低于治疗前, 且研究组低于对照组, 差异有统计学意义(P < 0.05);治疗后, 2组LVEF、CO和IGF-1水平高于治疗前, 且研究组高于对照组, 差异有统计学意义(P < 0.05)。
    结论 环磷腺苷葡胺联合单硝酸异山梨酯治疗可有效改善CHF患者心功能, 提高临床疗效。

     

    Abstract:
    Objective To investigate the therapeutic effect of meglumine adenosine cyclophosphate combined with isosorbide mononitrate for patients with chronic heart failure (CHF).
    Methods A total of 92 CHF patients were selected as study subjects, and randomly divided into control group and study group, with 46 patients in each group.The control group was treated with meglumine adenosine cyclophosphate, and the study group was treated with isosorbide mononitrate on the basis of the control group.Clinical efficacy, left ventricular enddiastolic volume (LVEDV), left ventricular endsystolic volume (LVESV), left ventricular ejection fraction (LVEF), cardiac output (CO), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), insulin growth factor-1(IGF-1), troponin T (cTnT) levels in two groups were observed.
    Results The total effective rate in the study group was 95.65%, which was significantly higher than 76.09% in the control group (P < 0.05).After treatment, the levels of LVEDV, LVESV, NT-proBNP and cTnT in two groups were significantly lower than before treatment, and the study group was significantly lower than the control group (P < 0.05);the LVEF, CO and IGF-1 levels of two groups after treatment were significantly higher than before treatment, and the study group was significantly higher than the control group (P < 0.05).
    Conclusion Meglumine adenosine cyclophosphate combined with isosorbide mononitrate in treatment of patients with CHF can effectively improve the cardiac function and clinical efficacy.

     

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