慢性阻塞性肺疾病合并抑郁患者的脑皮质边缘环路研究

王龙龙; 许淑娣; 马洪鸽; 马静文; 王警建; 杨淑涵; 张明

doi:10.7619/jcmp.20215107

慢性阻塞性肺疾病合并抑郁患者的脑皮质边缘环路研究

A research on cerebral limbic-cortical circuit in patients with chronic obstructive pulmonary disease complicated with depression

摘要

摘要:
目的应用基于体素形态学分析(VBM)探讨慢性阻塞性肺疾病(COPD)合并抑郁患者的皮质边缘环路脑灰质体积改变。
方法前瞻性选取22例COPD合并抑郁患者为COPD合并抑郁组，另选取性别、年龄相匹配的20例健康受试者为对照组。实施T2-FLAIR、高分辨3D-T1WI检查，采用慢性阻塞性肺疾病评估测试(CAT)及SPM12软件分析2组脑灰质体积变化。
结果 VBM结果显示, 与对照组相比, COPD合并抑郁患者左侧额叶、双侧中央旁小叶、双侧前扣带回、左中部扣带回、左后扣带回、左背侧丘脑、下丘脑、双侧杏仁体、双侧小脑灰质体积减少，差异有统计学意义(P < 0.05)。
结论 COPD合并抑郁患者存在皮质边缘环路的多个脑区灰质体积减少情况，可为临床预防、治疗及干预提供参考。

Abstract:
Objective To explore the change of gray matter volume in limbic-cortical circuit in patients with chronic obstructive pulmonary disease (COPD)complicated with depression by using voxel-based morphometry (VBM).
Methods A total of 22 patients with COPD complicated with depression were prospectively selected as COPD complicated with depression group, and 20 healthy subjects matched by gender and age were selected as control group. T2-FLAIR and high-resolution 3d-T1WI were performed, and the change of cerebral gray matter volume in both groups was analyzed by COPDAssessment Test (CAT) and SPM12 software.
Results The results of VBM showed that the volumes of gray matter in left frontal lobe, bilateral paracentral lobules, bilateral anterior cingulate gyrus, left central and left posterior cingulate gyrus, left dorsal thalamus, hypothalamus, bilateral amygdala and bilateral cerebellum significantly decreased in patients with COPD complicated with depression compared with the control group (P < 0.05).
Conclusion Patients with COPD complicated with depression present gray matter volume reduction in multiple regions of limbic-cortical circuitry, which can provide reference for clinical prevention, treatment and intervention.

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