Research progress on mechanism of ferroptosis and its role in fibrotic diseases
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摘要:
铁死亡是一种重要的细胞死亡方式，主要由铁依赖性氧化损伤引起，受铁代谢和脂质过氧化信号调控。细胞内铁代谢失衡、氧化还原状态受到破坏会促进细胞铁死亡的发生。近年来，越来越多研究发现在肝纤维化及肺纤维化疾病的病理过程中，存在铁积累和脂质过氧化物堆积现象，表明铁死亡参与了纤维化疾病的发生发展。本文对铁死亡在肝纤维化和肺纤维化疾病中发挥的不同调控作用进行总结，综述了在不同纤维化疾病中针对铁死亡相关机制抑制纤维化进展的有效药物，提出了纤维化疾病中针对铁死亡机制的潜在治疗靶点，为临床治疗纤维化疾病的新型靶向药物研发指明了方向。
Abstract:Ferroptosis is an important way of cell death, which is mainly caused by iron-dependent oxidative damage and regulated by iron metabolism and lipid peroxidation signals. Imbalance of iron metabolism and the destruction of redox state in cells will promote the occurrence of cell iron death. In recent years, more and more studies have found that iron accumulation and lipid peroxide accumulation exist in the pathological process of liver fibrosis and pulmonary fibrosis, indicating that iron death is involved in the occurrence and development of fibrosis. This study summarized the different regulatory roles of iron death in liver fibrosis and pulmonary fibrosis, reviewed the effective drugs that inhibit the progression of fibrosis according to the mechanisms related to iron death in different fibrosis diseases, and proposed the potential therapeutic targets for iron death mechanism in fibrosis diseases, which pointed out the direction for the research and development of new targeted drugs for the clinical treatment of fibrotic diseases.
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Keywords:
- ferroptosis /
- liver fibrosis /
- pulmonary fibrosis /
- lipid peroxidation /
- nano reactors /
- artemisinin
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