Abstract: Ferroptosis is an important way of cell death, which is mainly caused by iron-dependent oxidative damage and regulated by iron metabolism and lipid peroxidation signals. Imbalance of iron metabolism and the destruction of redox state in cells will promote the occurrence of cell iron death. In recent years, more and more studies have found that iron accumulation and lipid peroxide accumulation exist in the pathological process of liver fibrosis and pulmonary fibrosis, indicating that iron death is involved in the occurrence and development of fibrosis. This study summarized the different regulatory roles of iron death in liver fibrosis and pulmonary fibrosis, reviewed the effective drugs that inhibit the progression of fibrosis according to the mechanisms related to iron death in different fibrosis diseases, and proposed the potential therapeutic targets for iron death mechanism in fibrosis diseases, which pointed out the direction for the research and development of new targeted drugs for the clinical treatment of fibrotic diseases.