Objective  To investigate the efficacy of aspirin combined with atorvastatin in treatment of patients with symptomatic intracranial atherosclerotic disease plaque stenosis.

  Methods  The clinical data of 40 patients with symptomatic ICAD stenosis were retrospectively analyzed and they were randomly divided into observation group and control group, with 20 cases in each group. The control group was treated with aspirin, and the observation group was given atorvastatin on the basis of the control group treatment. The total effective rate after medication, improvement of arterial plaque and neurological deficit score before and after medication were compared between the two groups.

  Results  After treatment, the total effective rate of the observation group was significantly higher than that of the control group (P < 0.05); the intracranial arterial plaque area in the observation group was significantly smaller, and the intracranial plaque thickness in stenosis segment under high resolution magnetic resonance was significantly greater than that in the control group (P < 0.05); after treatment, the neurological deficit score of the observation group was significantly lower than that of the control group (P < 0.05).

  Conclusion  Application of aspirin combined with atorvastatin in the treatment of symptomatic ICAD stenosis has a significant effect, which can improve the degree of neurological impairment, increase the thickness of arterial plaque, and reduce the area of arterial plaque.