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初诊2型糖尿病患者并发糖尿病周围神经病变的相关危险因素分析

Related risk factors for diabetic peripheral neuropathy in newly diagnosed patients with type 2 diabetes mellitus

    摘要
  • 摘要:
    目的 探讨广东惠州地区初诊2型糖尿病(T2DM)患者并发糖尿病周围神经病变(DPN)的相关危险因素。
    方法 选取2020年1月-2021年6月于惠州市中心人民医院内分泌科病房住院治疗的84例初诊T2DM患者作为研究对象, 依据有无DPN分为DPN组51例(男33例, 女18例)和对照组33例(男19例, 女14例)。比较2组患者的一般资料和生化指标水平, 并比较患者双侧正中神经、尺神经、胫神经、腓总神经的运动传导速度(MNCV)和感觉传导速度(SNCV)。采用Spearman相关分析法分析组间差异有统计学意义的指标与初诊T2DM患者并发DPN的相关性, 并采用多因素非条件Logistic回归分析法分析DPN的危险因素。
    结果 DPN组患者年龄、糖化血红蛋白(HbA1c)水平、体质量下降速度、吸烟率高于对照组, 入院时体质量、体质量指数(BMI)低于对照组, 差异有统计学意义(P < 0.05);DPN组正中神经、尺神经的MNCV和正中神经、尺神经、胫神经、腓总神经的SNCV均低于对照组, 差异有统计学意义(P < 0.05)。Spearman相关分析结果提示, DPN与年龄、HbA1c、体质量下降速度、吸烟均呈显著正相关(P < 0.05);多因素非条件Logistic回归分析提示, 年龄大、HbA1c水平高、体质量下降速度快是初诊T2DM患者并发DPN的独立危险因素(P < 0.05)。
    结论 广东惠州地区初诊T2DM患者并发DPN的独立危险因素包括年龄大、HbA1c水平高和体质量下降速度快。

     

    Abstract:
    Objective To explore the related risk factors for diabetic peripheral neuropathy (DPN) in newly diagnosed patients with type 2 diabetes mellitus (T2DM) in Huizhou of Guangdong Province.
    Methods A total of 84 hospitalized patients with newly diagnosed T2DM from January 2020 to June 2021 in the ward of department of endocrinology in Huizhou Central People′s Hospital were selected as study objects and were divided into DPN group (n=51, 33 males and 18 females) and control group (n=33, 19 males and 14 females) based on whether they had DPN or not.The general data and biochemical indexes of two groups were compared, and the motor conduction velocity (MNCV) and sensory conduction velocity (SNCV) of median nerve, ulnar nerve, tibial nerve and common peroneal nerve were compared.Spearman correlation analysis was used to analyze the correlation between indicators with statistical significance and DPN in newly diagnosed T2DM patients, and multivariate unconditional Logistic regression analysis was used to analyze the risk factors of DPN.
    Results Compared with control group, age, glycosylated hemoglobin A1c (HbA1c) level, the velocity of weight loss and the rate of smoking were significantly higher than those in the control group, the body weight and body mass index (BMI) at admission were significantly lower than those in the control group (P < 0.05).MNCV of median nerve and ulnar nerve and SNCV of median nerve, ulnar nerve, tibial nerve and common peroneal nerve in the DPN group were lower than those in the control group, the differences were statistically significant (P < 0.05).Spearman correlation analysis showed that age, HbA1c, the velocity of weight loss and smoking were positively correlated with DPN in patients with newly diagnosed T2DM (P < 0.05).Multivariate unconditional Logistic regression analysis showed that older age, elevated HbA1c andrapid weight loss were the independent risk factors for DPN in newly diagnosed T2DM patients (P < 0.05).
    Conclusion Older age, elevated HbA1c and the rapid weight loss are the risk factors for the occurrence of DPN in patients newly diagnosed as T2DM in Huizhou of Guangdong Province.

     

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