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全段成纤维细胞生长因子23与维持性血液透析患者肾性贫血的相关性研究

Relation between intact fibroblast growth factor 23 and renal anemia in maintenance hemodialysis patients

    摘要
  • 摘要:
      目的  探讨全段成纤维细胞生长因子23（iFGF23）与维持性血液透析（MHD）患者肾性贫血的相关性。
      方法  根据纳入标准和排除标准筛选研究对象，收集其一般资料及实验室检查资料。采用酶联免疫吸附法检测透析患者血清iFGF23，并做相关性和多重线性回归分析。
      结果  本研究共纳入MHD患者138例，平均血红蛋白（Hb）水平为（105.0±19.0）g/L，其中79例Hb水平超过110 g/L，肾性贫血控制达标率为57.2%。按肾性贫血控制达标情况将患者分为2组，达标组的iFGF23水平低于未达标组，差异有统计学意义（P < 0.05）。MHD患者Hb水平与红细胞比容（HCT）、血清白蛋白（Alb）、白细胞（WBC）呈正相关（P < 0.05），与收缩压（SBP）、血肌酐（Scr）、铁蛋白（Fer）、Ln（iFGF23）呈负相关（P < 0.05）。多重线性回归分析显示，低血清Alb、高Scr、高Ln（iFGF23）是MHD患者发生肾性贫血的独立预测因子。
      结论  Ln（iFGF23）与MHD患者肾性贫血的发生风险有关，其机制有待进一步阐明。

     

    Abstract:
      Objective  To investigate the correlation between intact fibroblast growth factor 23 (iFGF23) and renal anemia in patients with maintenance hemodialysis (MHD).
      Methods  Subjects were screened according to inclusion and exclusion criteria, and their general information and laboratory examination data were collected. Serum iFGF23 of dialysis patients was detected by enzyme linked immunosorbent assay, and correlation and multiple linear regression analysis were performed.
      Results  A total of 138 MHD patients were included in this study. The overall hemoglobin (Hb) level was (105.0±19.0) g/L, and exceeded 110 g/L in 79 (57.2%) cases, with the standardization rate of renal anemia control of 57.2%. Patients were divided into two groups according to the standard of renal anemia control, and the level of iFGF23 in the standard group was lower than that in the non-standard group (P < 0.05). The level of Hb in MHD patients was positively correlated with erythrocyte volume (HCT), serum albumin (Alb), white blood cell (WBC) (P < 0.05), and negatively correlated with systolic blood pressure (SBP), serum creatinine (Scr), ferritin (Fer), and Ln(iFGF23) (P < 0.05). Multiple linear regression analysis showed that low serum Alb, high Scr, and high Ln (iFGF23) were independent predictors of renal anemia in MHD patients.
      Conclusion  Ln (iFGF23) is associated with risk of renal anemia in MHD patients, and its mechanism needs to be further elucidated.

     

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