Abstract: Adult scaphoid necrosis of foot (Müller-Weiss disease) is usually distributed bilaterally, and the patients initially have symptoms of foot pain and complicated scaphoid deformity, and then followed by progressive necrosis of the scaphoid, and finally evolve into the formation of flat foot and "cuneonavicular joint" due to compensatory decline of the internal foot arch. Surgical treatment is a preferred choice when the conservative treatment is failed. This paper reviewed the clinical features, imaging features, differential diagnosis and therapeutic methods of Müller-Weiss disease.