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SEPT9基因甲基化、生长分化因子15、糖类抗原199与结直肠癌患者临床病理特征和预后的关系

Correlations between expressions of SEPT9 gene methylation, growth differentiation factor 15, carbohydrate antigen 199 and clinicopathologic features, prognosis in patients with colorectal cancer

    摘要
  • 摘要:
      目的  探讨结直肠癌患者血浆SEPT9基因甲基化（mSEPT9）、生长分化因子15（GDF15）、糖类抗原199（CA199）表达与临床病理特征和预后的关系。
      方法  回顾性分析218例肛肠科住院患者的血液样本，将106例结直肠癌患者纳入癌症组，将112例结直肠腺瘤患者纳入腺瘤组。另将同期体检中心的100例健康体检者纳入对照组。比较3组研究对象的mSEPT9、GDF15、CA199阳性率，探讨mSEPT9、GDF15、CA199与结直肠癌患者临床病理特征及预后的关系。
      结果  癌症组mSEPT9阳性率和GDF15、CA199水平高于腺瘤组和对照组，且腺瘤组高于对照组，差异有统计学意义（P < 0.05）；mSEPT9、GDF15、CA199在TNM分期为Ⅲ~Ⅳ期、浸润深度为浆膜层以下、分化程度为低分化、有淋巴结转移和远处转移密切的患者中表达更高，差异有统计学意义（P < 0.05）；Pearson相关性分析显示，mSEPT9、GDF15、CA199与TNM分期、浸润深度、分化程度、淋巴结转移、远处转移显著相关（P < 0.05）；临床分期高、分化程度低、淋巴结转移、远处转移以及mSEPT9、GDF15、CA199阳性表达是结直肠癌患者预后不良的独立危险因素（P < 0.05）。
      结论  结直肠癌患者mSEPT9、GDF15、CA199表达显著升高，且与不同临床病理特征密切相关，mSEPT9、GDF15、CA199阳性表达是患者预后不良的独立危险因素，临床应加强干预，从而改善患者预后，提高其生存率。

     

    Abstract:
      Objective  To investigate the expressions of SEPT9 gene methylation (mSEPT9), growth differentiation factor 15 (GDF15) and carbohydrate antigen 199 (CA199) in patients with colorectal cancer, and to analyze their relationships with clinicopathological features and prognosis.
      Methods  Blood samples from 218 inpatients admitted to the Anorectal Department were retrospectively analyzed, including 106 patients with colorectal cancer in cancer group and 112 patients with colorectal adenoma in adenoma group. A total of 100 healthy people were collected as control group. The positive rates of mSEPT9, GDF15 and CA199 in the three groups were compared, and the relationships between mSEPT9, GDF15, CA199 and clinicopathological features, prognosis of colorectal cancer patients were investigated.
      Results  The positive rate of mSEPT9, levels ofGDF15 and CA199 in the cancer group were significantly higher than those in the adenoma group and the control group, and were higher in the adenoma group than those in the control group (P < 0.05). The levels of mSEPT9, GDF15 and CA199TNM in patients in stage Ⅲ to Ⅳ, infiltration depth below serosal layer, low differentiation, lymph node metastasis and distant metastasis were significantly increased (P < 0.05). Pearson correlation analysis showed that mSEPT9, GDF15, CA199 were significantly correlated with TNM stage, infiltration depth, differentiation degree, lymph node metastasis and distant metastasis (P < 0.05). High clinical stage, low degree of differentiation, lymph node metastasis, distant metastasis and positive expressions of mSEPT9, GDF15 and CA199 were independent risk factors for poor prognosis in colorectal cancer patients (P < 0.05).
      Conclusion  The expressions of mSEPT9, GDF15, and CA199 in colorectal cancer patients are significantly increased, and are closely related to different clinicopathological features. Positive expressions of mSEPT9, GDF15, and CA199 are independent risk factors for poor prognosis. Clinical intervention should be strengthened to improve the prognosis and survival rate of patients.

     

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