Objective  To explore levels and significance of asymmetric dimethylarginine (ADMA), Annexin V, and Survivin in the serum and placental tissues of preeclamptic patients.

  Methods  A total of 60 hospitalized preeclampsia patients in department of obstetrics were selected as preeclampsia group, and another 60 healthy pregnant women in department of obstetrics during the same period were selected as healthy pregnant group. The expression levels of ADMA, Annexin V and Survivin in serum and placenta samples from preeclamptic patients were analyzed, and their correlations were analyzed.

  Results  The ADMA expression levels in the maternal serum and placental tissues in the preeclampsia group were higher than those in healthy pregnant women, and the expression levels of Annexin V and Survivin were lower than those in healthy pregnant group (P < 0.05). ADMA expression levels in serum and placental tissues of early-onset preeclampsia patients were higher than those of late-onset preeclampsia patients, and Annexin V and Survivin expression levels were lower than those of late-onset preeclampsia patients (P < 0.05). ADMA expression levels in serum and placental tissues of mild preeclampsia patients were lower than those of severe preeclampsia patients, and Annexin V and Survivin expression levels were higher than those of severe preeclampsia patients (P < 0.05). There were negative correlations between ADMA and Annexin V (r=-0.481, P=0.001), between ADMA and Survivin (r=-0.683, P=0.001). ADMA and Survivin was positively correlated (r=0.495, P=0.001).

  Conclusion  ADMA, Annexin V and Survivin are specifically expressed in the serum and placental tissue of patients with preeclampsia, and they have close relationships with the severity of the disease, which provide a new theoretical reference for the diagnosis and treatment of preeclampsia in clinical practice.