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原发性干燥综合征相关间质性肺疾病的发生率及危险因素分析

Analysis of incidence of primary Sj gren syndrome associated with interstitial lung disease and its risk factors

    摘要
  • 摘要:
      目的  分析原发性干燥综合征（pSS）相关间质性肺疾病（ILD）的发生率及危险因素。
      方法  回顾性纳入278例pSS患者，按照肺部高分辨CT检查结果分为pSS-ILD组（n=83）与pSS组（n=195）。统计pSS-ILD的发生率；比较2组的基线资料、临床症状、实验室指标；分析pSS-ILD的危险因素。
      结果  278例pSS患者中，发生pSS-ILD患者83例（29.86%）。pSS-ILD组年龄大于pSS组，吸烟史比例、咳嗽、咳痰及胸闷气喘发生率高于pSS组，差异有统计学意义（P < 0.05）。pSS-ILD组白细胞（WBC）、嗜中性粒细胞、补体C3、补体C4水平以及抗核抗体滴度、抗SSA抗体阳性率高于pSS组，差异有统计学意义（P < 0.05）。年龄（OR=0.814，95% CI为0.620~1.147，P < 0.001）、吸烟史（OR=0.712，95% CI为0.557~0.960，P=0.013）及抗核抗体滴度（OR=0.764，95% CI为0.528~0.995，P=0.021）是pSS患者发生ILD的独立影响因素（P < 0.05）。
      结论  本研究中pSS-ILD的发生率较高，高龄、吸烟及高抗核抗体滴度提示pSS患者发生ILD的风险明显增高。

     

    Abstract:
      Objective  To analyze the incidence of primary Sj gren syndrome (pSS) associated with interstitial lung disease (ILD) and its risk factors.
      Methods  A total of 278 patients with pSS were retrospectively enrolled and divided into pSS-ILD group (n=83) and pSS group (n=195) according to the results of lung high-resolution CT examination. The incidence of pSS-ILD was analyzed, and the baseline data, clinical symptoms and laboratory indicators of the two groups were compared. The risk factors of pSS-ILD were analyze.
      Results  Among 278 patients with pSS, 83 cases (29.86%) developed pSS-ILD. The age of the pSS-ILD group was significantly higher, and the proportion of smoking history, incidence of cough, expectoration, chest tightness and asthma were significantly higher than those of the pSS group (P < 0.05). The levels of white blood cell (WBC), neutrophil, complement C3, complement C4, antinuclear antibody titer and anti-SSA antibody positive rate in pSS-ILD group were significantly higher than those in the pSS group (P < 0.05). The multivariate age(OR=0.814, 95%CI, 0.620 to 1.147, P < 0.001), smoking history(OR=0.712, 95%CI, 0.557 to 0.960, P=0.013) and antinuclear antibody titer(OR=0.764, 95%CI, 0.528 to 0.995, P=0.021) were independent influencing factors for ILD in pSS patients (P < 0.05).
      Conclusion  In this study, the incidence of pSS-ILD is high. Advanced age, smoking and high antinuclear antibody titer suggest that the risk of ILD is significantly increased in pSS patients.

     

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