Objective  To analyze the correlations between levels of serum ischemia modified albumin (IMA), monocyte chemoattractant protein-1 (MCP-1) and neurological function recovery during convalescence in patients with acute cerebral infarction (ACI) after thrombolysis.

  Methods  A total of 40 ACI patients with poor neurological function and 40 ACI patients with good neurological function during convalescence after thrombolysis were selected as poor recovery group and good recovery group. The laboratory examination data and baseline data of the two groups were collected, and the correlations between the levels of serum IMA, MCP-1 and the neurological function recovery during convalescence after ACI thrombolysis were analyzed.

  Results  The levels of serum IMA and MCP-1 in the poor recovery group were significantly higher than those in the good recovery group (P < 0.05). There was a positive correlation between serum IMA level and MCP-1 level in ACI patients (r=0.580, P < 0.001), and the over-expressions of serum IMA and MCP-1 levels were associated with poor neurological function recovery during convalescence after ACI thrombolysis (OR > 1, P < 0.05). The area under curve (AUC) of serum IMA and MCP-1 levels alone and their combination to predict the risk of poor neurological function recovery during convalescence in patients with ACI after thrombolysis were greater than 0.80.

  Conclusion  The over-expression of IMA and MCP-1 may be related to the poorneurological function recovery during convalescence in patients with ACI after thrombolysis.