血清缺血修饰白蛋白及单核细胞趋化蛋白-1水平与急性脑梗死溶栓后恢复期神经功能恢复的相关性

郭婷婷; 杜华平; 邱卓胤; 吴燕华

doi:10.7619/jcmp.20212556

血清缺血修饰白蛋白及单核细胞趋化蛋白-1水平与急性脑梗死溶栓后恢复期神经功能恢复的相关性

Correlations between levels of serum ischemia modified albumin, monocyte chemoattractant protein-1 and neurological function recovery during convalescence in patients with acute cerebral infarction after thrombolysis

摘要

摘要:
目的分析血清缺血修饰白蛋白(IMA)、单核细胞趋化蛋白-1(MCP-1)水平与急性脑梗死(ACI)溶栓后恢复期神经功能恢复的关系。
方法将40例ACI溶栓后恢复期神经功能恢复不良患者和40例神经功能恢复良好患者分别设为恢复不良组和恢复良好组。收集2组实验室检查资料、基线资料，分析血清IMA、MCP-1水平与ACI溶栓后恢复期神经功能恢复的关系。
结果恢复不良组血清IMA、MCP-1水平高于恢复良好组，差异有统计学意义(P < 0.05)。ACI患者血清IMA水平与MCP-1水平呈显著正相关(r=0.580, P < 0.001), 血清IMA、MCP-1水平过表达与ACI溶栓后恢复期神经功能恢复不良有关(OR > 1, P < 0.05)。血清IMA、MCP-1水平单独及联合预测ACI溶栓后恢复期神经功能恢复不良风险的曲线下面积(AUC)均 > 0.80。
结论 ACI溶栓后恢复期患者神经功能恢复不良可能与IMA、MCP-1的过表达有关。

Abstract:
Objective To analyze the correlations between levels of serum ischemia modified albumin (IMA), monocyte chemoattractant protein-1 (MCP-1) and neurological function recovery during convalescence in patients with acute cerebral infarction (ACI) after thrombolysis.
Methods A total of 40 ACI patients with poor neurological function and 40 ACI patients with good neurological function during convalescence after thrombolysis were selected as poor recovery group and good recovery group. The laboratory examination data and baseline data of the two groups were collected, and the correlations between the levels of serum IMA, MCP-1 and the neurological function recovery during convalescence after ACI thrombolysis were analyzed.
Results The levels of serum IMA and MCP-1 in the poor recovery group were significantly higher than those in the good recovery group (P < 0.05). There was a positive correlation between serum IMA level and MCP-1 level in ACI patients (r=0.580, P < 0.001), and the over-expressions of serum IMA and MCP-1 levels were associated with poor neurological function recovery during convalescence after ACI thrombolysis (OR > 1, P < 0.05). The area under curve (AUC) of serum IMA and MCP-1 levels alone and their combination to predict the risk of poor neurological function recovery during convalescence in patients with ACI after thrombolysis were greater than 0.80.
Conclusion The over-expression of IMA and MCP-1 may be related to the poorneurological function recovery during convalescence in patients with ACI after thrombolysis.

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