Abstract: Pancreatic cancer is a major cause of cancer-associated mortality. The 5-year survival rate is only 9%. Surgical resection reminds the primary curative treatment for long-term survival in patients and the 5-year survival rate can be increased to 50% after surgery combined with chemotherapy. As the incidence and early detection rate increasing, the number of patients undergoing surgical resection is increasing. Due to the high complexity of pancreatectomy, domestic clinical and research only focus on mortality, complications, and perioperative treatment, ignoring the patient's physiological function, psychosocial and social function, symptoms, and other feelings related to the quality of life. This article reviewed domestic and foreign research results related to current quality of life and intervention strategies for pancreatic cancer patients, so as to provide reference for clinical practice and future research.